Shahine M Y, Moustafa A S
J Egypt Soc Parasitol. 1989 Dec;19(2):733-41.
Twenty patients with confirmed bilharzial hepatic fibrosis and similar number of matched normal controls were investigated for their plasma protein C activity, prothrombin time and partial thromboplastin time. The results showed marked decrease in plasma protein C activity together with the expected prolongation in prothrombin and partial thromboplastin times. Since protein C exhibits a controlling mechanism on haemostasis by inhibition of activated factor V, changes in plasma protein C activity will necessarily impart an effect on blood coagulation.
对20例确诊为血吸虫性肝纤维化的患者以及数量与之匹配的正常对照者进行了血浆蛋白C活性、凝血酶原时间和部分凝血活酶时间的检测。结果显示，血浆蛋白C活性显著降低，同时凝血酶原时间和部分凝血活酶时间出现预期的延长。由于蛋白C通过抑制活化的因子V对止血发挥控制机制，血浆蛋白C活性的变化必然会对血液凝固产生影响。
