Amin H M, Omran S A, el-Bassuoni N E, el-Kaliouby A H, el-Ashmawy S A
Department of Hematology, Theodor Bilharz Research Institute, Giza, Egypt.
Haemostasis. 1994 Jan-Feb;24(1):22-6. doi: 10.1159/000217076.
Forty-four patients with schistosomiasis mansoni were divided into two groups: a group of 31 patients with hepatosplenomegaly and a group of 13 patients with advanced hepatic fibrosis and ascites. Both groups were compared to a control group of 14 healthy subjects. Screening of the extrinsic and intrinsic coagulation pathways was performed by PT (%) and aPTT. Functional assays of vitamin-K-dependent coagulation proteins: factors II, VII, IX, X, and protein C were conducted by using standard methods. A progressive reduction in PT (%) and prolongation in aPTT were detected in the diseased groups. Furthermore, all studied coagulation proteins showed a progressive reduction in their activities, which became more pronounced in the group with advanced ascites. We conclude that the significant reduction in vitamin-K-dependent coagulation proteins might add to the coagulopathy and bleeding diathesis noted in patients infected with Schistosoma mansoni.
44例曼氏血吸虫病患者被分为两组：一组31例有肝脾肿大，另一组13例有晚期肝纤维化和腹水。两组均与14名健康受试者组成的对照组进行比较。通过PT（%）和活化部分凝血活酶时间（aPTT）对外源性和内源性凝血途径进行筛查。采用标准方法对维生素K依赖的凝血蛋白（因子II、VII、IX、X和蛋白C）进行功能测定。在患病组中检测到PT（%）逐渐降低，aPTT延长。此外，所有研究的凝血蛋白活性均逐渐降低，在有晚期腹水的组中更为明显。我们得出结论，维生素K依赖的凝血蛋白显著降低可能会加重曼氏血吸虫病感染患者的凝血病和出血素质。
