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雏鸡视网膜中高亲和力胆碱摄取和胆碱乙酰转移酶的不同发育时间进程。

Different time course of development for high-affinity choline uptake and choline acetyltransferase in the chick retina.

作者信息

Bader C R, Baughman R W, Moore J L

出版信息

Proc Natl Acad Sci U S A. 1978 May;75(5):2525-9. doi: 10.1073/pnas.75.5.2525.

DOI:10.1073/pnas.75.5.2525
PMID:276888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC392587/
Abstract

Synthesis and storage of [3H]acetylcholine in isolated pieces of chick retina increased in two stages during embryogenesis. The first increase coincided with a 100-fold rise in the activity of choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), but during the second increase the activity of this enzyme remained essentially constant. The second increase instead was linked to an approximately 6-fold increase in the Vmax for high-affinity uptake of choline.

摘要

在鸡胚视网膜分离片段中，[3H]乙酰胆碱的合成与储存在胚胎发育过程中分两个阶段增加。第一次增加与胆碱乙酰转移酶（乙酰辅酶A：胆碱O-乙酰转移酶，EC 2.3.1.6）活性升高100倍同时发生，但在第二次增加过程中，该酶的活性基本保持不变。相反，第二次增加与胆碱高亲和力摄取的Vmax增加约6倍有关。

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引用本文的文献

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Two molecular weight forms of muscarinic acetylcholine receptors in the avian central nervous system: switch in predominant form during differentiation of synapses.鸟类中枢神经系统中两种分子量形式的毒蕈碱型乙酰胆碱受体：突触分化过程中主要形式的转换。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8785-9. doi: 10.1073/pnas.82.24.8785.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Correlations of structural and biochemical changes in the developing retina of the chick.雏鸡发育中视网膜的结构与生化变化的相关性
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The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.从大脑中分离神经末梢：对通过匀浆和离心获得的细胞碎片进行的电子显微镜研究。
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Localization of acetylcholinesterase in chick retina during histogenesis.组织发生过程中鸡视网膜内乙酰胆碱酯酶的定位
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Control of acetylcholine synthesis--the inhibition of choline acetyltransferase by acetylcholine.乙酰胆碱合成的调控——乙酰胆碱对胆碱乙酰转移酶的抑制作用。
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9
Acetylcholinesterase and choline acetyltransferase activity in the developing chick spinal cord.发育中的雏鸡脊髓中的乙酰胆碱酯酶和胆碱乙酰转移酶活性
J Exp Zool. 1968 Sep;169(1):107-12. doi: 10.1002/jez.1401690112.
10
Purification and properties of choline acetyltransferase from ox brain striate nuclei.牛脑纹状体核中胆碱乙酰转移酶的纯化及性质
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