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准分子原位角膜磨镶术联合加速角膜胶原交联治疗近视的疗效与安全性：六个月研究

Efficacy and Safety of LASIK Combined with Accelerated Corneal Collagen Cross-Linking for Myopia: Six-Month Study.

作者信息

Wu Ying, Tian Lei, Wang Li-Qiang, Huang Yi-Fei

机构信息

Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.

出版信息

Biomed Res Int. 2016;2016:5083069. doi: 10.1155/2016/5083069. Epub 2016 Sep 4.

DOI:10.1155/2016/5083069
PMID:27689082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5027044/
Abstract

This was a prospective controlled clinical trial. 48 myopia patients (96 eyes) were included in this study. After LASIK, accelerated corneal collagen cross-linking (ACXL) was used for myopia treatment. During 6-month follow-up, the results of LASIK-ACXL treatment were studied and compared to the LASIK-only procedure. The results showed that no statistically significant differences in UDVA, CDVA, MRSE, mean, pachymetry, or ECD were found between the two groups at the visit after 6 months of follow-up (all > 0.05). At 6 months postoperatively, 2 eyes lost one or more lines of visual acuity in the LASIK-ACXL group, whereas all LASIK-only treated eyes had a stable CDVA. confocal microscopy showed a decrease of keratocyte density and appearance of honeycomb-like structures in the anterior residual stroma bed; the changes were similar but more pronounced following LASIK-only. None of the cases in both groups developed signs of significant keratitis, regression, or ectasia during the 6-month follow-up. LASIK-ACXL can effectively correct refractive error in patients with myopia, with no significant complications during 6-month follow-up, indicating stability and morphologic change similar to those with LASIK-only treatment.

摘要

这是一项前瞻性对照临床试验。本研究纳入了48例近视患者（96只眼）。准分子激光原位角膜磨镶术（LASIK）后，采用加速角膜胶原交联（ACXL）治疗近视。在6个月的随访期间，研究了LASIK-ACXL治疗的结果，并与单纯LASIK手术进行了比较。结果显示，随访6个月后的复诊时，两组在最佳矫正视力（UDVA）、矫正视力（CDVA）、平均残余散光（MRSE）、平均值、角膜厚度测量或角膜内皮细胞密度（ECD）方面均未发现统计学上的显著差异（均>0.05）。术后6个月时，LASIK-ACXL组有2只眼视力下降一行或多行，而所有单纯LASIK治疗的眼睛矫正视力均稳定。共聚焦显微镜检查显示，前弹力层下剩余基质床的角膜细胞密度降低，出现蜂窝状结构；单纯LASIK术后的变化相似但更明显。两组患者在6个月的随访期间均未出现明显的角膜炎、回退或角膜扩张迹象。LASIK-ACXL可有效矫正近视患者的屈光不正，在6个月的随访期间无明显并发症，表明其稳定性和形态学变化与单纯LASIK治疗相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/f6cd218f3b54/BMRI2016-5083069.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/c5cb5023b88b/BMRI2016-5083069.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/31e68ff04816/BMRI2016-5083069.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/8b6f7b3b51ba/BMRI2016-5083069.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/d41662c818a0/BMRI2016-5083069.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/f6cd218f3b54/BMRI2016-5083069.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/c5cb5023b88b/BMRI2016-5083069.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/31e68ff04816/BMRI2016-5083069.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/8b6f7b3b51ba/BMRI2016-5083069.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/d41662c818a0/BMRI2016-5083069.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebbf/5027044/f6cd218f3b54/BMRI2016-5083069.005.jpg

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