Kitanaka T, Hidaka A
Department of Obstetrics and Gynecology, Osaka City University Medical School.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Jun;41(6):669-75.
We have shown that the changes in renal blood flow (RBF) and renal sympathetic nerve activity (R-SNA) in metreurysis are different on the ovarian side from those on the cervical side. We examined their dissimilar mechanisms, and the changes in noradrenaline in the renal vein under metreurysis as an indicator of SNA and we also explored the pathway of Utero-Renal Reflex. In pregnant rabbits, SNA was measured by using bipolar electrode and renal cortical blood flow was measured by the thermocouple method. Noradrenaline was measured by HPLC. A small balloon was inserted into the uterine cavity on the ovarian or cervical side to increase the uterine resting tonus (URT). Noradrenaline increased under metreurysis with the increase in R-SNA. After protecting the abdominal large vessels an increase in URT in the cervical side caused the elevation of mean blood pressure, an increase in R-SNA and a decrease in RBF. After blocking the nerve around the suspensory ligaments an increase in URT in ovarian side did not cause an increase in R-SNA or a decrease in RBF. These data indicate that an increase in URT can stimulate R-SNA through the Utero-Renal Reflex, which in turn causes the deterioration of renal circulation.
我们已经表明，在子宫收缩时，卵巢侧和宫颈侧的肾血流量（RBF）及肾交感神经活动（R-SNA）变化不同。我们研究了它们不同的机制，以及子宫收缩时肾静脉中去甲肾上腺素的变化作为交感神经活动的指标，并且我们还探索了子宫-肾反射的途径。在怀孕兔子中，使用双极电极测量交感神经活动，采用热电偶法测量肾皮质血流量。通过高效液相色谱法测量去甲肾上腺素。在卵巢侧或宫颈侧的子宫腔内插入一个小气球以增加子宫静息张力（URT）。随着R-SNA的增加，子宫收缩时去甲肾上腺素增加。在保护腹部大血管后，宫颈侧URT的增加导致平均血压升高、R-SNA增加和RBF降低。在阻断悬韧带周围的神经后，卵巢侧URT的增加并未导致R-SNA增加或RBF降低。这些数据表明，URT的增加可通过子宫-肾反射刺激R-SNA，进而导致肾循环恶化。
