Domaracki Piotr, Sadlecki Pawel, Odrowaz-Sypniewska Grazyna, Dzikowska Ewa, Walentowicz Pawel, Siodmiak Joanna, Grabiec Marek, Walentowicz-Sadlecka Malgorzata
Department of Obstetrics and Gynecology, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, ul. Ujejskiego 75, Bydgoszcz 85-168, Poland.
Department of Laboratory Medicine, L. Rydygier Collegium in Bydgoszcz, Nicolaus Copernicus University, M. Curie Skłodowskiej 9, Bydgoszcz 85-094, Poland.
Int J Mol Sci. 2016 Sep 27;17(10):1574. doi: 10.3390/ijms17101574.
An association between the level of vitamin D and the risk of pregnancy-related complications remains unclear. The aim of this study was to examine concentrations of 25(OH) vitamin D in Polish women with normal pregnancies and pregnancies complicated by gestational hypertension, preeclampsia or gestational diabetes mellitus (GDM). Moreover, we analyzed an association between maternal serum 25(OH)D and the risk of gestational hypertension, preeclampsia and GDM.
The study included 207 pregnant women, among them 171 with pregnancy-related complications: gestational hypertension ( = 45), preeclampsia ( = 23) or GDM ( = 103). The control group consisted of 36 women with normal pregnancies. Concentrations of serum 25(OH)D were measured at admission to the hospital prior to delivery Results: Patients with hypertension did not differ significantly from the controls in terms of their serum 25(OH)D concentrations (18.20 vs. 22.10 ng/mL, = 0.15). Highly significant differences were found in 25(OH)D concentrations of women with preeclampsia and the controls (14.75 vs. 22.10 ng/mL, = 0.0021). GDM was not associated with significant differences in 25(OH)D concentration. A low level of 25(OH)D turned out to be associated with an increased risk of preeclampsia during pregnancy on both univariate and multivariate regression analysis, and was a significant predictor of this condition on ROC (receiver operating characteristic) analysis (AUC = 0.70, < 0.01).
25(OH)D deficiency is common among pregnant Polish women. Low concentrations of 25(OH)D may play a role in the etiopathogenesis of preeclampsia. Routine assessment of the 25(OH)D level during pregnancy may be crucial for the identification of women at increased risk of preeclampsia.
维生素D水平与妊娠相关并发症风险之间的关联尚不清楚。本研究旨在检测正常妊娠以及并发妊娠期高血压、子痫前期或妊娠期糖尿病（GDM）的波兰女性的25（OH）维生素D浓度。此外，我们分析了孕妇血清25（OH）D与妊娠期高血压、子痫前期和GDM风险之间的关联。
该研究纳入了207名孕妇，其中171名患有妊娠相关并发症：妊娠期高血压（n = 45）、子痫前期（n = 23）或GDM（n = 103）。对照组由36名正常妊娠的女性组成。在入院分娩前测定血清25（OH）D浓度。结果：高血压患者的血清25（OH）D浓度与对照组相比无显著差异（18.20对22.10 ng/mL，P = 0.15）。子痫前期女性与对照组的25（OH）D浓度存在高度显著差异（14.75对22.10 ng/mL，P = 0.0021）。GDM与25（OH）D浓度的显著差异无关。单因素和多因素回归分析均显示，低水平的25（OH）D与妊娠期子痫前期风险增加相关，并且在ROC（受试者工作特征）分析中是该疾病的显著预测指标（AUC = 0.70，P < 0.01）。
25（OH）D缺乏在波兰孕妇中很常见。低浓度的25（OH）D可能在子痫前期的发病机制中起作用。孕期常规评估25（OH）D水平对于识别子痫前期风险增加的女性可能至关重要。
