细菌透明质酸酶自触发前药释放用于协同治疗细菌感染的化疗-光热治疗。
Bacterial Hyaluronidase Self-Triggered Prodrug Release for Chemo-Photothermal Synergistic Treatment of Bacterial Infection.
机构信息
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Graduate School University of Chinese Academy of Sciences, Beijing, 100039, China.
出版信息
Small. 2016 Dec;12(45):6200-6206. doi: 10.1002/smll.201601729. Epub 2016 Sep 30.
A novel platform for targeted on-demand prodrug ascorbic acid (AA) delivery is fabricated using a bacterial hyaluronidase sensitive graphene-mesoporous silica nanosheet@hyaluronic acid-magnetic nanoparticles as the nanocarrier to treat bacterial infections. The released AA can be converted to detrimental •OH in situ on the surface of bacteria. With the chemo-photothermal synergistic effect, the designed antibacterial system can effectively inactivate bacteria and disperse stubborn biofilm.
一种新型的靶向按需前体药物抗坏血酸（AA）递送平台是使用细菌透明质酸酶敏感的石墨烯-介孔硅纳米片@透明质酸-磁性纳米颗粒作为纳米载体来治疗细菌感染而构建的。释放的 AA 可以在细菌表面原位转化为有害的 •OH。通过化学-光热协同作用，设计的抗菌系统可以有效地灭活细菌并分散顽固的生物膜。
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