Svensson P, Kumar A
Section of Orofacial Pain and Jaw Function, Institute of Odontology and Oral Health, Aarhus University, Aarhus, Denmark.
Department of Dental Medicine, Karolinska Institute, Huddinge, Sweden.
J Oral Rehabil. 2016 Dec;43(12):977-989. doi: 10.1111/joor.12447. Epub 2016 Oct 20.
Oro-facial pain research has during the last decades provided important novel insights into the basic underlying mechanisms, the need for standardised diagnostic procedures and classification systems, and multiple treatment options for successful rehabilitation of the patient in pain. Notwithstanding the significant progress in our knowledge spanning from molecules to chair, there may also be limitations in our ability to integrate and interpret the tremendous amount of new data and information, in particular in terms of the clinical implications and overriding conceptual models for oro-facial pain. The aim of the present narrative review is to briefly summarise some of the current thoughts on oro-facial pain mechanisms and recent attempts to identify biomarkers and risk factors leading to the proposal of a new risk assessment diagram for oro-facial pain (RADOP) and a provocative new concept based on stochastic variation between multiple risk factors. Finally, the implications for novel management strategies will briefly be discussed.
在过去几十年中，口腔面部疼痛研究为深入了解其基本潜在机制、标准化诊断程序和分类系统的必要性以及为疼痛患者成功康复提供多种治疗选择提供了重要的新见解。尽管我们在从分子到临床的知识方面取得了重大进展，但我们整合和解释大量新数据和信息的能力可能仍存在局限性，特别是在口腔面部疼痛的临床意义和首要概念模型方面。本叙述性综述的目的是简要总结当前关于口腔面部疼痛机制的一些观点，以及最近识别生物标志物和风险因素的尝试，从而提出一种新的口腔面部疼痛风险评估图（RADOP）以及基于多种风险因素之间随机变化的一个引人深思的新概念。最后，将简要讨论对新型管理策略的影响。
