Wu Xueqiang, Li Zefang, Cui Yiping, Yan Zhaojun, Lu Tingting, Cui Song
Department of Health Science, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of the First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Genet. 2024 Mar 8;15:1365596. doi: 10.3389/fgene.2024.1365596. eCollection 2024.
This study aims to clarify the incidence rate of temporomandibular joint disease in patients with mental disorders. Data extracted from the Psychiatric Genomics Consortium and FinnGen databases employed the Mendelian Randomization (MR) method to assess the associations of three neurodevelopmental disorders (NDDs)-Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Tourette's Disorder (TD)-as exposure factors with Temporomandibular Disorder (TMD). The analysis used a two-sample MR design, employing the Inverse Variance Weighted (IVW) method to evaluate the relationships between these disorders and Temporomandibular Disorder. Sensitivity analysis and heterogeneity assessments were conducted. Potential confounding factors like low birth weight, childhood obesity, and body mass index were controlled for. The study found that ADHD significantly increased the risks for TMD (OR = 1.2342, 95%CI (1.1448-1.3307), < 0.00001), TMD (including avohilmo) (OR = 1.1244, 95%CI (1.0643-1.1880), = 0.00003), TMD-related pain (OR = 1.1590, 95%CI (1.0964-1.2252), < 0.00001), and TMD-related muscular pain associated with fibromyalgia (OR = 1.1815, 95%CI (1.1133-1.2538), < 0.00001), while other disorders did not show significant causal relationships. This study reveals the elevated risk of various TMD aspects due to ADHD. Furthermore, we discuss the link between low vitamin D levels ADHD and TMD. Future research should address these limitations and delve further into the complex interactions between ADHD, ASD, TD, and TMD.
本研究旨在阐明精神障碍患者颞下颌关节疾病的发病率。从精神疾病基因组学联盟和芬兰基因数据库提取的数据采用孟德尔随机化（MR）方法，评估三种神经发育障碍（NDDs）——注意力缺陷多动障碍（ADHD）、自闭症谱系障碍（ASD）和抽动秽语综合征（TD）——作为暴露因素与颞下颌关节紊乱病（TMD）之间的关联。分析采用两样本MR设计，运用逆方差加权（IVW）方法评估这些障碍与颞下颌关节紊乱病之间的关系。进行了敏感性分析和异质性评估。对低出生体重、儿童肥胖和体重指数等潜在混杂因素进行了控制。研究发现，ADHD显著增加了患TMD的风险（OR = 1.2342，95%CI（1.1448 - 1.3307），< 0.00001）、TMD（包括关节盘移位）（OR = 1.1244，95%CI（1.0643 - 1.1880），= 0.00003）、TMD相关疼痛（OR = 1.1590，95%CI（1.0964 - 1.2252），< 0.00001）以及与纤维肌痛相关的TMD相关肌肉疼痛（OR = 1.1815，95%CI（1.1133 - 1.2538），< 0.00001），而其他障碍未显示出显著的因果关系。本研究揭示了ADHD导致各种TMD方面风险升高。此外，我们讨论了低维生素D水平与ADHD和TMD之间的联系。未来的研究应解决这些局限性，并进一步深入研究ADHD、ASD、TD和TMD之间的复杂相互作用。
