Gould S J, Graham J
Department of Histopathology, University College and Middlesex School of Medicine, London.
J Laryngol Otol. 1989 Jun;103(6):622-5. doi: 10.1017/s0022215100109521.
In neonates, acquired subglottic stenosis (SGS) is the most serious long term complication of endotracheal intubation. In this case report, we describe the pathological changes in the larynx of a child who died two years after successful treatment, involving corrective surgery, for neonatally acquired SGS. Stenosis, due to dense fibrous connective tissue, was still present at death. However, there was evidence that there had been growth of the laryngeal cartilages. Disruption of the laryngeal cartilages was present anteriorly due to the antecedent surgery but major cricoid cartilage injury secondary to intubation was not seen. The crico-arytenoid joints demonstrated ankylosis and to this was attributed the abnormal quality of voice noted in the child at follow-up. The pathological changes are considered in relation to the pathology of endotracheal intubation and pathogenesis of acquired subglottic stenosis.
在新生儿中，获得性声门下狭窄（SGS）是气管插管最严重的长期并发症。在本病例报告中，我们描述了一名儿童喉部的病理变化，该儿童在成功接受针对新生儿期获得性SGS的矫正手术治疗两年后死亡。直至死亡时，由于致密纤维结缔组织导致的狭窄仍然存在。然而，有证据表明喉软骨有生长。由于先前的手术，喉部软骨前部出现破坏，但未发现插管继发的主要环状软骨损伤。环杓关节表现为关节强硬，这被认为是随访中该儿童声音异常的原因。结合气管插管的病理学和获得性声门下狭窄的发病机制对这些病理变化进行了探讨。
