Adriaansen F C, Hoeve L J, Verwoerd-Verhoef H L, van der Heul R O, Verwoerd C D
Department of Otorhinolaryngology, Erasmus University Rotterdam, The Netherlands.
Int J Pediatr Otorhinolaryngol. 1992 May;23(3):221-7. doi: 10.1016/0165-5876(92)90103-v.
In an experimental study in growing rabbits an endolaryngeal injury to the subglottis resulted in the development of a stenosis due to the formation of scar tissue containing ectopic cartilage. For comparison, biopsies taken from the subglottic stenosis in 8 children were studied histologically. In 6 cases ectopic cartilage was observed; all patients had a history of endotracheal intubation. In 3 children the diagnosis hamartoma was made. In the remaining 3 cases the formation of ectopic cartilage might have been a direct reaction to the endolaryngeal intubation. The observations suggest that the formation of ectopic cartilage in acquired subglottic stenosis is not always due to a developmental aberration such as a hamartoma.
