Deon Valeria, Del Bò Cristian, Guaraldi Federica, Gargari Giorgio, Bosusco Andrea, Simonetti Paolo, Riso Patrizia, Guardamagna Ornella
a Department of Food, Environmental and Nutritional Sciences, Division of Human Nutrition , Università degli Studi di Milano , Milan , Italy.
b Department of Health, Sciences and Pediatric , Università degli Studi di Torino , Turin , Italy.
Int J Food Sci Nutr. 2017 May;68(3):339-348. doi: 10.1080/09637486.2016.1236076. Epub 2016 Oct 3.
This study aimed at characterizing the fatty acid (FA) composition of red blood cell (RBC) phospholipids in children and adolescents with primary hyperlipidemia, and to ascertain potential association with serum lipid profile and dietary factors. At this purpose, 54 probands aged 6-17 years were recruited. Subjects showed a low omega-3 index (eicosapentaenoic acid, EPA + docosahexaenoic acid, DHA <4%). Compared to males, females had a trend toward lower levels of total monounsaturated fatty acids (MUFA) and MUFA/saturated fatty acids (SFAs) ratio in RBCs. An inverse relationship between MUFA concentration in RBCs and serum cholesterol or HDL-C/triglycerides ratio was found. Omega-6 polyunsaturated fatty acids (n-6 PUFA) were positively associated to serum HDL-C levels, and inversely to dietary cholesterol. Fiber intake was positively associated with MUFA/SFA ratio. In conclusion, we provide the first experimental data on phospholipid FA composition of RBCs in hyperlipidemic children, showing sex differences and an overall low omega 3-index.
本研究旨在表征原发性高脂血症儿童和青少年红细胞（RBC）磷脂的脂肪酸（FA）组成，并确定其与血脂谱和饮食因素的潜在关联。为此，招募了54名6至17岁的先证者。受试者的ω-3指数较低（二十碳五烯酸，EPA + 二十二碳六烯酸，DHA <4%）。与男性相比，女性红细胞中总单不饱和脂肪酸（MUFA）水平和MUFA/饱和脂肪酸（SFA）比值有降低趋势。发现红细胞中MUFA浓度与血清胆固醇或HDL-C/甘油三酯比值呈负相关。ω-6多不饱和脂肪酸（n-6 PUFA）与血清HDL-C水平呈正相关，与饮食胆固醇呈负相关。纤维摄入量与MUFA/SFA比值呈正相关。总之，我们提供了关于高脂血症儿童红细胞磷脂FA组成的首个实验数据，显示了性别差异和总体较低的ω-3指数。
