Guerado Enrique, Cervan Ana M, Bertrand Maria L, Benitez-Parejo Nicolas
Department of Orthopaedic Surgery and Traumatology, Hospital Universitario Costa del Sol, University of Malaga, Spain.
Department of Orthopaedic Surgery and Traumatology, Hospital Universitario Costa del Sol, University of Malaga, Spain.
Injury. 2016 Sep;47 Suppl 3:S78-S82. doi: 10.1016/S0020-1383(16)30611-8.
To study the results of the combination of allograft plus BMP-7 in comparison with allograft alone in posterolateral lumbar arthrodesis.
A blinded controlled consecutive prospective cohort of skeletally mature patients study. One hundred and ten patients underwent posterolateral lumbar instrumented arthrodesis. Allograft randomly compacted onto either the right or the left side of the articular and the posterior aspect of the transverse processes of lumbar spine. The same procedure performed on the contralateral side, but allograft was previously mixed with osteogenic protein (OP-1). Clinical, x-ray and CT-scan long follow-up performed. Univariable and multivariable logistic regression analyses.
More bone continuity was found with allograft plus OP-1 than with allograft alone (p>0.0038). The amount of bone mass was greater on the OP-1 side (p<0.001). No local or systemic adverse effect were noted.
Allograft on one side plus allograft with BMP-7 on the other achieved a fusion rate of 93 per cent. Allograft combined with BMP-7 was more effective than allograft alone.
研究同种异体骨联合骨形态发生蛋白-7（BMP-7）与单纯同种异体骨用于腰椎后外侧融合术的效果对比。
一项针对骨骼成熟患者的前瞻性队列双盲对照研究。110例患者接受了腰椎后外侧器械融合术。将同种异体骨随机紧密植入腰椎关节突关节右侧或左侧以及横突后侧。对侧进行相同操作，但同种异体骨预先与成骨蛋白（OP-1）混合。进行临床、X线及CT扫描长期随访，并进行单变量和多变量逻辑回归分析。
与单纯同种异体骨相比，同种异体骨联合OP-1时骨连续性更好（p>0.0038）。OP-1侧的骨量更多（p<0.001）。未观察到局部或全身不良反应。
一侧使用同种异体骨，另一侧使用同种异体骨联合BMP-7，融合率达到93%。同种异体骨联合BMP-7比单纯同种异体骨更有效。
