Mesenchymal Stem Cell Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5001, Australia.
Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia.
Int J Mol Sci. 2020 Dec 21;21(24):9759. doi: 10.3390/ijms21249759.
There has been an escalation in reports over the last decade examining the efficacy of bone marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and regenerative medicine-based applications. The multipotent differentiation potential, myelosupportive capacity, anti-inflammatory and immune-modulatory properties of BMSC underpins their versatile nature as therapeutic agents. This review addresses the current limitations and challenges of exogenous autologous and allogeneic BMSC based regenerative skeletal therapies in combination with bioactive molecules, cellular derivatives, genetic manipulation, biocompatible hydrogels, solid and composite scaffolds. The review highlights the current approaches and recent developments in utilizing endogenous BMSC activation or exogenous BMSC for the repair of long bone and vertebrae fractures due to osteoporosis or trauma. Current advances employing BMSC based therapies for bone regeneration of craniofacial defects is also discussed. Moreover, this review discusses the latest developments utilizing BMSC therapies in the preclinical and clinical settings, including the treatment of bone related diseases such as Osteogenesis Imperfecta.
在过去十年中，关于骨髓间充质干细胞（BMSC）在骨组织工程和基于再生医学的应用中的功效的报告不断增加。BMSC 的多能分化潜能、骨髓支持能力、抗炎和免疫调节特性是其作为治疗剂的多功能性质的基础。本综述讨论了外源性自体和同种异体 BMSC 再生骨骼疗法与生物活性分子、细胞衍生物、基因操作、生物相容性水凝胶、固体和复合支架结合的当前局限性和挑战。该综述强调了当前利用内源性 BMSC 激活或外源性 BMSC 修复骨质疏松或创伤引起的长骨和椎骨骨折的方法和最新进展。还讨论了当前利用基于 BMSC 的疗法进行颅面缺损骨再生的进展。此外，本综述还讨论了利用 BMSC 疗法在临床前和临床环境中的最新进展，包括治疗骨相关疾病，如成骨不全症。
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