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非酒精性脂肪性肝病、与心血管疾病的关联及治疗。(一)非酒精性脂肪性肝病及其与心血管疾病的关联。

Nonalcoholic fatty liver disease, association with cardiovascular disease and treatment. (I). Nonalcoholic fatty liver disease and its association with cardiovascular disease.

作者信息

Brea Ángel, Pintó Xavier, Ascaso Juan F, Blasco Mariano, Díaz Ángel, González-Santos Pedro, Hernández Mijares Antonio, Mantilla Teresa, Millán Jesús, Pedro-Botet Juan

机构信息

Unidad de Lípidos, Servicio de Medicina Interna, Hospital San Pedro, Logroño, España.

Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario de Bellvitge, Idibell. CiberObn, L'Hospitalet de Llobregat, Barcelona, España.

出版信息

Clin Investig Arterioscler. 2017 May-Jun;29(3):141-148. doi: 10.1016/j.arteri.2016.06.003. Epub 2016 Sep 28.

Abstract

Non-alcoholic fatty liver disease (NAFLD) comprises a series of histologically lesions similar to those induced by alcohol consumption in people with very little or no liver damage. The importance of NAFLD is its high prevalence in the Western world and, from the point of view of the liver, in its gradual progression from steatosis to steatohepatitis, cirrhosis, and liver cancer. During the last decade it has been observed that NAFLD leads to an increased cardiovascular risk with acceleration of arteriosclerosis and events related to it, being the main cause of its morbidity and mortality. This review, updated to January 2016, consists of two parts, with the first part analysing the association of NAFLD with cardiovascular disease.

摘要

非酒精性脂肪性肝病(NAFLD)包括一系列组织学病变,这些病变与饮酒导致的病变相似,但发生在肝脏损伤极小或无肝脏损伤的人群中。NAFLD的重要性在于其在西方世界的高患病率,从肝脏角度来看,在于其从脂肪变性逐渐发展为脂肪性肝炎、肝硬化和肝癌。在过去十年中,人们观察到NAFLD会导致心血管风险增加,加速动脉硬化及其相关事件,这是其发病和死亡的主要原因。本综述更新至2016年1月,分为两部分,第一部分分析NAFLD与心血管疾病的关联。

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