Bai Lipeng, Li Danting, Li Jie, Luo Zhengzhong, Yu Shumin, Cao Suizhong, Shen Liuhong, Zuo Zhicai, Ma Xiaoping
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu, Sichuan 611130, China.
Acta Histochem. 2016 Oct;118(8):761-769. doi: 10.1016/j.acthis.2016.09.006. Epub 2016 Sep 28.
Umbilical cord mesenchymal stem cells (UCMSCs) retain their intrinsic stem cell potential while at the same time displaying high proliferation rates, powerful differentiation capacity, and low immunogenicity. They can also secrete multiple bioactive molecules that exert specific physiological functions. Thus, UCMSCs represent excellent candidates for cell therapy in regenerative medicine and tissue engineering. Abundant preclinical research on different disease models has shown that UCMSCs can accelerate wound or nerve damage recovery and suppress tumor progression. In fact, UCMSCs are thought to possess a higher therapeutic potential than MSCs derived from other tissues. Increasing evidence suggests that the mechanism underlying UCSMCs efficacy depends mostly on cell secretions, in contrast to the early paradigm of cell replacement and differentiation. In this review, we discuss UCMSCs biological characteristics, their secretome-based therapeutic mechanism, and potential applications.
脐带间充质干细胞（UCMSCs）保留了其内在的干细胞潜能，同时表现出高增殖率、强大的分化能力和低免疫原性。它们还能分泌多种发挥特定生理功能的生物活性分子。因此，UCMSCs是再生医学和组织工程中细胞治疗的理想候选者。对不同疾病模型进行的大量临床前研究表明，UCMSCs可以加速伤口或神经损伤的恢复，并抑制肿瘤进展。事实上，人们认为UCMSCs比源自其他组织的间充质干细胞具有更高的治疗潜力。越来越多的证据表明，与早期的细胞替代和分化模式不同，UCMSCs发挥疗效的机制主要依赖于细胞分泌。在这篇综述中，我们讨论了UCMSCs的生物学特性、基于其分泌组的治疗机制以及潜在应用。
