血脂与阿尔茨海默病的关联：综合脂质组学分析。

Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis.

机构信息

King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK.

King's College London, Institute of Pharmaceutical Science, London, UK.

出版信息

Alzheimers Dement. 2017 Feb;13(2):140-151. doi: 10.1016/j.jalz.2016.08.003. Epub 2016 Sep 28.

DOI:10.1016/j.jalz.2016.08.003

PMID:27693183

Abstract

INTRODUCTION

The aim of this study was to (1) replicate previous associations between six blood lipids and Alzheimer's disease (AD) (Proitsi et al 2015) and (2) identify novel associations between lipids, clinical AD diagnosis, disease progression and brain atrophy (left/right hippocampus/entorhinal cortex).

METHODS

We performed untargeted lipidomic analysis on 148 AD and 152 elderly control plasma samples and used univariate and multivariate analysis methods.

RESULTS

We replicated our previous lipids associations and reported novel associations between lipids molecules and all phenotypes. A combination of 24 molecules classified AD patients with >70% accuracy in a test and a validation data set, and we identified lipid signatures that predicted disease progression (R = 0.10, test data set) and brain atrophy (R ≥ 0.14, all test data sets except left entorhinal cortex). We putatively identified a number of metabolic features including cholesteryl esters/triglycerides and phosphatidylcholines.

DISCUSSION

Blood lipids are promising AD biomarkers that may lead to new treatment strategies.

摘要

简介

本研究旨在（1）复制先前六类血脂与阿尔茨海默病（AD）之间的关联（Proitsi 等人，2015 年），（2）确定血脂与临床 AD 诊断、疾病进展和脑萎缩（左侧/右侧海马体/内嗅皮层）之间的新关联。

方法

我们对 148 名 AD 患者和 152 名老年对照组的血浆样本进行了非靶向脂质组学分析，并使用了单变量和多变量分析方法。

结果

我们复制了先前的脂质关联，并报告了脂质分子与所有表型之间的新关联。24 种分子的组合可在测试和验证数据集上将 AD 患者正确分类为>70%，我们还确定了预测疾病进展（R=0.10，测试数据集）和脑萎缩（R≥0.14，所有测试数据集，除了左侧内嗅皮层）的脂质特征。我们推测鉴定了一些代谢特征，包括胆固醇酯/甘油三酯和磷脂酰胆碱。