Fazli Yousef, Shariatinia Zahra, Kohsari Iraj, Azadmehr Amirreza, Pourmortazavi Seied Mahdi
Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran.
Department of Chemistry, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-4413, Tehran, Iran.
Int J Pharm. 2016 Nov 20;513(1-2):636-647. doi: 10.1016/j.ijpharm.2016.09.078. Epub 2016 Sep 29.
Antimicrobial chitosan-polyethylene oxide (CS-PEO) nanofibrous mats containing ZnO nanoparticles (NPs) and hydrocortisone-imipenem/cilastatin-loaded ZnO NPs were produced by electrospinning technique. The FE-SEM images displayed that the spherical ZnO NPs were ∼70-200nm in size and the CS-PEO nanofibers were very uniform and free of any beads which had average diameters within the range of ∼20-130nm. For all of the nanofibrous mats, the water uptakes were the highest in acidic medium but they were decreased in the buffer and the least swellings were obtained in the alkaline environment. The drug incorporated mat preserved its bactericidal activity even after it was utilized in the release experiment for 8days in the PBS buffer. The hydrocortisone release was increased to 82% within first 12h while the release rate of imipenem/cilastatin was very much slower so that 20% of the drug was released during this period of time suggesting this nanofibrous mat is very suitable to inhibit inflammation (by hydrocortisone) and infection (using imipenem/cilastatin antibiotic and ZnO NPs) principally for the wound dressing purposes.
通过静电纺丝技术制备了含有氧化锌纳米颗粒（NPs）以及负载氢化可的松-亚胺培南/西司他丁的氧化锌纳米颗粒的抗菌壳聚糖-聚环氧乙烷（CS-PEO）纳米纤维垫。场发射扫描电子显微镜（FE-SEM）图像显示，球形氧化锌纳米颗粒的尺寸约为70-200nm，CS-PEO纳米纤维非常均匀，没有任何珠粒，其平均直径在约20-130nm范围内。对于所有纳米纤维垫，在酸性介质中的吸水率最高，但在缓冲液中有所降低，在碱性环境中膨胀最小。即使在PBS缓冲液中进行8天的释放实验后，载药垫仍保持其杀菌活性。氢化可的松在前12小时内的释放率提高到82%，而亚胺培南/西司他丁的释放速率则慢得多，在此期间20%的药物被释放，表明这种纳米纤维垫非常适合用于抑制炎症（通过氢化可的松）和感染（使用亚胺培南/西司他丁抗生素和氧化锌纳米颗粒），主要用于伤口敷料。
