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前列腺癌成像与治疗:纳米颗粒的潜在作用

Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles.

作者信息

Kilcoyne Aoife, Harisinghani Mukesh G, Mahmood Umar

机构信息

Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.

Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts

出版信息

J Nucl Med. 2016 Oct;57(Suppl 3):105S-110S. doi: 10.2967/jnumed.115.170738.

Abstract

Over the last 2 decades, the use of nanoparticle imaging has been investigated extensively for both diagnosis and therapy of prostate cancer. This review discusses the various classes of nanoparticles currently in clinical use or at the advanced preclinical stage. In particular, we focus on the unique properties of nanoparticles, as a group, that make them suitable for imaging and therapy. The characteristics of each nanoparticle are detailed. Iron oxide nanoparticles, extensively used for MRI of prostate cancer, are discussed in depth.

摘要

在过去20年里,纳米颗粒成像在前列腺癌的诊断和治疗方面得到了广泛研究。本综述讨论了目前正在临床使用或处于临床前高级阶段的各类纳米颗粒。特别是,我们关注纳米颗粒作为一个整体所具有的使其适用于成像和治疗的独特性质。详细介绍了每种纳米颗粒的特性。深入讨论了广泛用于前列腺癌MRI的氧化铁纳米颗粒。

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