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用于动脉粥样硬化和心肌梗死的诊断和治疗的纳米颗粒：向有前途的治疗诊断方法的演进。

Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches.

机构信息

Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Químicas y Farmaceuticas, Universidad de Chile, Santiago 8380492, Chile.

Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago 8380494, Chile.

出版信息

Theranostics. 2018 Sep 9;8(17):4710-4732. doi: 10.7150/thno.26284. eCollection 2018.

DOI:10.7150/thno.26284
PMID:30279733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6160774/
Abstract

Cardiovascular diseases are the leading cause of death worldwide. Despite preventive efforts, early detection of atherosclerosis, the common pathophysiological mechanism underlying cardiovascular diseases remains elusive, and overt coronary artery disease or myocardial infarction is often the first clinical manifestation. Nanoparticles represent a novel strategy for prevention, diagnosis, and treatment of atherosclerosis, and new multifunctional nanoparticles with combined diagnostic and therapeutic capacities hold the promise for theranostic approaches to this disease. This review focuses on the development of nanosystems for therapy and diagnosis of subclinical atherosclerosis, coronary artery disease, and myocardial infarction and the evolution of nanosystems as theranostic tools. We also discuss the use of nanoparticles in noninvasive imaging, targeted drug delivery, photothermal therapies together with the challenges faced by nanosystems during clinical translation.

摘要

心血管疾病是全球范围内的主要致死原因。尽管采取了预防措施，但动脉粥样硬化这一常见的心血管疾病病理生理机制仍难以早期检测到，并且明显的冠状动脉疾病或心肌梗死通常是其首次临床表现。纳米颗粒为动脉粥样硬化的预防、诊断和治疗提供了一种新策略，具有联合诊断和治疗能力的新型多功能纳米颗粒有望为这种疾病的治疗方法带来新的希望。本文重点介绍了用于治疗和诊断亚临床动脉粥样硬化、冠状动脉疾病和心肌梗死的纳米系统的发展，以及纳米系统作为治疗工具的演变。我们还讨论了纳米颗粒在无创成像、靶向药物输送、光热疗法中的应用，以及纳米系统在临床转化过程中所面临的挑战。

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