Zea-Vera A F, Parra B
Microbiology Department, Health faculty, Universidad del Valle, Cali, Colombia.
Lupus. 2017 Jul;26(8):890-892. doi: 10.1177/0961203316671816. Epub 2016 Sep 30.
A 30-year-old Colombian woman with past history of immune thrombocytopenia (ITP) presented to the emergency room with two days of global headache, arthralgia, myalgia, and low level fever and generalized erythematous rash. Platelets dropped to 9 × 10/L (fourth day of symptoms) without hemorrhagic manifestations but recovered to 30 × 10/L in 24 hours (fifth day). Dengue virus infection, as well as other viral infections, was ruled out. Zika virus (ZIKV) was evaluated in serum and urine samples by real-time reverse-transcriptase polymerase chain reaction (genomic regions within E protein and NS2b protein). Urine sample was positive and serum sample negative for ZIKV, confirming a recent ZIKV infection with urinary tract virus excretion at 7 day after disease onset. To our knowledge this is the first description of a case of severe immune thrombocytopenia exacerbation and antinuclear antibody positivity induced by ZIKV infection.
一名30岁有免疫性血小板减少症（ITP）病史的哥伦比亚女性因持续两天的全头痛、关节痛、肌痛、低热和全身性红斑皮疹就诊于急诊室。血小板降至9×10/L（症状出现第四天），无出血表现，但在24小时内（第五天）恢复至30×10/L。登革热病毒感染以及其他病毒感染均被排除。通过实时逆转录聚合酶链反应（E蛋白和NS2b蛋白内的基因组区域）对血清和尿液样本进行寨卡病毒（ZIKV）评估。尿液样本ZIKV呈阳性，血清样本呈阴性，证实近期感染ZIKV且发病7天后尿路有病毒排泄。据我们所知，这是首例关于寨卡病毒感染诱发严重免疫性血小板减少症加重和抗核抗体阳性的病例描述。
