Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogotá, Colombia.
Autoimmun Rev. 2017 Dec;16(12):1237-1245. doi: 10.1016/j.autrev.2017.10.008. Epub 2017 Oct 14.
Zika virus (ZIKV) infection has been associated with the development of Guillain-Barré syndrome (GBS) and idiopathic thrombocytopenic purpura (ITP). Whether ZIKV infection is related to other autoimmune diseases is unknown. Therefore, an association study to evaluate rheumatic and thyroid autoimmunity in patients with ZIKV disease was conducted through a panel of 14 autoantibodies. In addition, a literature review on ZIKV, and GBS and ITP was performed. Our results disclosed a lack of association of rheumatoid and thyroid autoimmunity with ZIKV disease. A total of 272 cases of GBS related to ZIKV were retrieved from the literature, the majority of them being males (54.8%). Electrophysiological findings indicated acute inflammatory demyelinating polyneuropathy as the most frequent subphenotype (75.7%). Up to date, twenty-four cases of ITP in patients with ZIKV disease have been published. Although a few fatal cases have been observed, most of the reported patients responded well to immunomodulatory treatment. A review of the mechanisms incriminated into the development of autoimmune phenomenon in ZIKV disease indicates molecular mimicry as the most plausible one. Nevertheless, more research aimed at deciphering ZIKV disease pathogenesis and its relationship with autoimmunity is warranted.
Zika 病毒（ZIKV）感染与吉兰-巴雷综合征（GBS）和特发性血小板减少性紫癜（ITP）的发生有关。ZIKV 感染是否与其他自身免疫性疾病有关尚不清楚。因此，通过一组 14 种自身抗体进行了一项评估 ZIKV 病患者风湿性和甲状腺自身免疫的关联研究。此外，还对 ZIKV、GBS 和 ITP 进行了文献复习。我们的研究结果表明，类风湿性和甲状腺自身免疫与 ZIKV 病无关。从文献中检索到 272 例与 ZIKV 相关的 GBS，其中大多数为男性（54.8%）。电生理学发现表明急性炎症性脱髓鞘性多发性神经病是最常见的亚型（75.7%）。迄今为止，已有 24 例 ZIKV 病患者并发 ITP 发表。尽管观察到少数致命病例，但大多数报道的患者对免疫调节治疗反应良好。对 ZIKV 病中自身免疫现象发展所涉及的机制的综述表明，分子模拟是最合理的机制之一。然而，需要更多的研究来阐明 ZIKV 病的发病机制及其与自身免疫的关系。
