Raymond W A, Leong A S
Division of Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia.
J Pathol. 1989 Jul;158(3):203-11. doi: 10.1002/path.1711580306.
Measurements of the growth fraction (GF) and oestrogen receptor (OR) status were performed by immunohistochemical staining, using the monoclonal antibodies Ki-67 and anti-OR, in consecutive cryostat sections of biopsies from 74 women with primary breast cancer, and 12 women with benign breast disease. A significant inverse correlation was identified between the GF and OR status (r = -0.452, P less than 0.0001), but a group of OR-positive tumours with high GFs was also observed. There was a strong positive correlation between immunocytochemically determined OR percentages and values obtained with a cytosolic OR biochemical assay for the 70 cases in which both techniques were performed (r = 0.801, P less than 0.0001). A significant relationship was also revealed between the histological grade of infiltrating ductal carcinomas and their associated GFs (r = 0.622, P less than 0.0001). No correlation was found between the GF and the number of positive axillary nodes. Our findings suggest that GF and OR status are useful independent prognostic parameters in breast cancer, but the former probably has an overriding influence. Both parameters may be useful guides for selection of appropriate endocrine and/or adjuvant chemotherapy.
采用单克隆抗体Ki-67和抗雌激素受体（anti-OR），通过免疫组织化学染色对74例原发性乳腺癌患者及12例乳腺良性疾病患者活检标本的连续冰冻切片进行生长分数（GF）和雌激素受体（OR）状态检测。结果发现GF与OR状态之间存在显著的负相关（r = -0.452，P < 0.0001），但也观察到一组OR阳性且GF高的肿瘤。对于70例同时采用两种技术检测的病例，免疫细胞化学测定的OR百分比与胞质OR生化检测获得的值之间存在强正相关（r = 0.801，P < 0.0001）。浸润性导管癌的组织学分级与其相关的GF之间也显示出显著关系（r = 0.622，P < 0.0001）。未发现GF与腋窝阳性淋巴结数目之间存在相关性。我们的研究结果表明，GF和OR状态是乳腺癌有用的独立预后参数，但前者可能具有更重要的影响。这两个参数可能是选择合适的内分泌和/或辅助化疗的有用指导。
