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Cushing's syndrome due to ectopic ACTH production by a nasal paraganglioma.鼻副神经节瘤异位分泌促肾上腺皮质激素所致的库欣综合征。
Endocrinol Diabetes Metab Case Rep. 2013;2013:130038. doi: 10.1530/EDM-13-0038. Epub 2013 Sep 16.
2
⁶⁸Ga-DOTATOC PET-CT in the localization of source of ectopic ACTH in patients with ectopic ACTH-dependent Cushing's syndrome.⁶⁸Ga-DOTATOC PET-CT 在异位 ACTH 依赖性库欣综合征患者异位 ACTH 源定位中的应用。
Clin Imaging. 2014 Mar-Apr;38(2):208-11. doi: 10.1016/j.clinimag.2013.10.007. Epub 2013 Nov 7.
3
Hypercortisolaemia due to ectopic adrenocorticotropic hormone secretion by a nasal paraganglioma: a case report and review of the literature.鼻腔副神经节瘤分泌异位促肾上腺皮质激素导致的高皮质醇血症：一例报告及文献复习
BMC Res Notes. 2013 Aug 19;6:331. doi: 10.1186/1756-0500-6-331.
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Images in clinical medicine. Ectopic Cushing's syndrome.
N Engl J Med. 2011 Dec 22;365(25):e46. doi: 10.1056/NEJMicm1010540.
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A case of catecholamine and glucocorticoid excess syndrome due to a corticotropin-secreting paraganglioma.一例因分泌促肾上腺皮质激素的副神经节瘤导致的儿茶酚胺和糖皮质激素过多综合征。
Ann N Y Acad Sci. 2006 Aug;1073:52-8. doi: 10.1196/annals.1353.006.
6
Paragangliomas: clinical overview.副神经节瘤：临床概述
Ann N Y Acad Sci. 2006 Aug;1073:21-9. doi: 10.1196/annals.1353.002.
7
Cushing's syndrome.库欣综合征
Lancet. 2006 May 13;367(9522):1605-17. doi: 10.1016/S0140-6736(06)68699-6.
8
Corticotropin-producing pulmonary gangliocytic paraganglioma associated with Cushing's syndrome.与库欣综合征相关的促肾上腺皮质激素分泌性肺神经节细胞瘤
Hum Pathol. 2006 May;37(5):623-6. doi: 10.1016/j.humpath.2005.12.006. Epub 2006 Mar 13.
9
The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up.异位促肾上腺皮质激素综合征：临床特征、诊断、管理及长期随访
J Clin Endocrinol Metab. 2006 Feb;91(2):371-7. doi: 10.1210/jc.2005-1542. Epub 2005 Nov 22.
10
An extra-adrenal abdominal pheochromocytoma causing ectopic ACTH syndrome.一例导致异位促肾上腺皮质激素综合征的肾上腺外腹部嗜铬细胞瘤。
Am J Hypertens. 2005 Oct;18(10):1364-8. doi: 10.1016/j.amjhyper.2005.01.019.

腹膜后分泌促肾上腺皮质激素的副神经节瘤所致异位库欣综合征

Ectopic Cushing's syndrome due to retroperitoneal ACTH-producing paragangliomas.

作者信息

Chen Fan, Wang Xiangyu, Wang Yang, Meng Hui, Hou Xinguo, Zhu Yaofeng, Gao Wei, Jiang Xuewen, Chen Shouzhen, Zhang Zhaocun, Zou Zhichuan, He Tianyi, Yang Yue, Zhu Kejia, Wang Yong, Liu Yaxiao, Cui Jianfeng, Shi Benkang, Yin Gang

机构信息

Department of Urology, Qilu Hospital, Shandong University, Jinan, Shandong, China;; College of Medicine, University of Kentucky, Lexington, KY, United States.

Department of Urology, The People's Hospital of Liaocheng, Liaocheng, Shandong, China.

出版信息

Can Urol Assoc J. 2016 Sep-Oct;10(9-10):E320-E323. doi: 10.5489/cuaj.3153. Epub 2016 Sep 13.

DOI:10.5489/cuaj.3153
PMID:27695589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5028219/
Abstract

Extra-adrenal pheochromocytomas, or paragangliomas, are rare tumours that derive from extra-adrenal chromaffin cells. Cushing's syndrome (CS) caused by paragangliomas is extremely rare. We report a 53-year-old man with hypertension, diabetes, and symptoms of hypokalemia. Computer tomography (CT) revealed two retroperitoneal masses and bilateral adrenal hyperplasia. Together with the laboratory examinations, ectopic CS caused by multiple paragangliomas was highly suspected. The patient underwent resections of retroperitoneal tumours, left kidney, and left adrenal; postoperative histopathology confirmed two paragangliomas that were both positively stained for adrenocorticotropic hormone (ACTH). He got clinical and biochemical recoveries without any recurrent evidence at the nine-month followup.

摘要

肾上腺外嗜铬细胞瘤，即副神经节瘤，是一种源于肾上腺外嗜铬细胞的罕见肿瘤。由副神经节瘤引起的库欣综合征（CS）极为罕见。我们报告一例53岁男性患者，有高血压、糖尿病及低钾血症症状。计算机断层扫描（CT）显示腹膜后有两个肿块及双侧肾上腺增生。结合实验室检查，高度怀疑是由多发副神经节瘤引起的异位性CS。患者接受了腹膜后肿瘤、左肾及左肾上腺切除术；术后组织病理学证实为两个副神经节瘤，两者促肾上腺皮质激素（ACTH）染色均为阳性。在9个月的随访中，患者临床及生化指标恢复正常，无任何复发迹象。