RNA编辑动态重写癌症密码。
RNA Editing Dynamically Rewrites the Cancer Code.
作者信息
Rayon-Estrada Violeta, Papavasiliou F Nina, Harjanto Dewi
机构信息
Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; The Rockefeller Graduate Program, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
出版信息
Trends Cancer. 2015 Dec;1(4):211-212. doi: 10.1016/j.trecan.2015.10.008. Epub 2015 Nov 26.
Abstract
Global analyses of cancer transcriptomes demonstrate that ADAR (adenosine deaminase, RNA-specific)-mediated RNA editing dynamically contributes to genetic alterations in cancer, and directly correlates with progression and prognosis. RNA editing is abundant and frequently elevated in cancer, and affects functionally and clinically relevant sites in both coding and non-coding regions of the transcriptome. Therefore, ADAR and differentially edited transcripts may be promising biomarkers or targets for therapy.
摘要
癌症转录组的全球分析表明，ADAR（RNA特异性腺苷脱氨酶）介导的RNA编辑动态地促成了癌症中的基因改变，并与进展和预后直接相关。RNA编辑在癌症中大量存在且经常升高，并影响转录组编码区和非编码区中功能和临床相关位点。因此，ADAR和差异编辑的转录本可能是有前景的生物标志物或治疗靶点。
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