The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel.
School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Cell Rep. 2015 Oct 13;13(2):267-76. doi: 10.1016/j.celrep.2015.08.080. Epub 2015 Oct 1.
Genomic mutations in key genes are known to drive tumorigenesis and have been the focus of much attention in recent years. However, genetic content also may change farther downstream. RNA editing alters the mRNA sequence from its genomic blueprint in a dynamic and flexible way. A few isolated cases of editing alterations in cancer have been reported previously. Here, we provide a transcriptome-wide characterization of RNA editing across hundreds of cancer samples from multiple cancer tissues, and we show that A-to-I editing and the enzymes mediating this modification are significantly altered, usually elevated, in most cancer types. Increased editing activity is found to be associated with patient survival. As is the case with somatic mutations in DNA, most of these newly introduced RNA mutations are likely passengers, but a few may serve as drivers that may be novel candidates for therapeutic and diagnostic purposes.
已知关键基因中的基因组突变会导致肿瘤发生，近年来一直是研究的重点。然而，遗传物质也可能在下游发生改变。RNA 编辑以动态和灵活的方式改变 mRNA 序列与其基因组蓝图的对应序列。以前曾有报道过一些癌症中编辑改变的孤立病例。在这里，我们对来自多种癌症组织的数百个癌症样本进行了全转录组范围内的 RNA 编辑特征描述，并表明 A 到 I 的编辑以及介导这种修饰的酶在大多数癌症类型中显著改变，通常是升高的。研究发现，编辑活性的增加与患者的生存有关。与 DNA 中的体细胞突变一样，这些新引入的 RNA 突变中的大多数可能是乘客突变，但少数可能是驱动突变，可能成为治疗和诊断目的的新候选者。
