Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Bioinformatics. 2012 Dec 1;28(23):3166-8. doi: 10.1093/bioinformatics/bts589. Epub 2012 Oct 7.
A-to-I RNA editing is an important mechanism that consists of the conversion of specific adenosines into inosines in RNA molecules. Its dysregulation has been associated to several human diseases including cancer. Recent work has demonstrated a role for A-to-I editing in microRNA (miRNA)-mediated gene expression regulation. In fact, edited forms of mature miRNAs can target sets of genes that differ from the targets of their unedited forms. The specific deamination of mRNAs can generate novel binding sites in addition to potentially altering existing ones.
This work presents miR-EdiTar, a database of predicted A-to-I edited miRNA binding sites. The database contains predicted miRNA binding sites that could be affected by A-to-I editing and sites that could become miRNA binding sites as a result of A-to-I editing.
miR-EdiTar is freely available online at http://microrna.osumc.edu/mireditar.
alessandro.lagana@osumc.edu or carlo.croce@osumc.edu
Supplementary data are available at Bioinformatics online.
A-to-I RNA 编辑是一种重要的机制，包括将 RNA 分子中特定的腺苷转换为肌苷。其失调与包括癌症在内的几种人类疾病有关。最近的研究表明，A-to-I 编辑在 microRNA（miRNA）介导的基因表达调控中起作用。事实上，成熟 miRNA 的编辑形式可以靶向与其未编辑形式不同的基因集。mRNA 的特异性脱氨作用除了可能改变现有结合位点外，还可以产生新的结合位点。
本研究介绍了 miR-EdiTar，这是一个预测 A-to-I 编辑 miRNA 结合位点的数据库。该数据库包含可能受 A-to-I 编辑影响的 miRNA 结合位点，以及可能因 A-to-I 编辑而成为 miRNA 结合位点的位点。
miR-EdiTar 可在 http://microrna.osumc.edu/mireditar 上免费在线获取。
alessandro.lagana@osumc.edu 或 carlo.croce@osumc.edu
补充数据可在 Bioinformatics 在线获取。
