Seibel W, Yahia N A, McCleary L B, Lesko L J, Hassell T M
Department of Anatomy, Dental School, University of Maryland, Baltimore 21201.
J Oral Pathol Med. 1989 Apr;18(4):240-5. doi: 10.1111/j.1600-0714.1989.tb00771.x.
Development of gingival overgrowth during daily long-term cyclosporine A treatment was studied in 2-yr-old beagles. Gingival enlargement developed in five of 12 dogs (42%), primarily in the mandibular anterior area. The earliest gingival changes occurred by 3 wk as an increase in the size of the interdental papillae. The lesions progressively became more severe, in some cases obscuring portions of teeth by wk 6. The redundant tissue exhibited an increase in connective tissue components and an inflammatory infiltrate primarily of plasma cells. Severity of the overgrowth varied in responding animals; both incidence and severity were related to the CSA concentration in blood. The mean CSA blood levels of responders were significantly greater than nonresponders at wk 3, 6 and 10. Since beagles develop gingival overgrowth similar to humans, they provide an excellent model to investigate the roles of local and systemic factors in the induction of gingival overgrowth.
在2岁的比格犬中研究了长期每日使用环孢素A治疗期间牙龈增生的发展情况。12只犬中有5只（42%）出现了牙龈肿大，主要发生在下颌前部区域。最早的牙龈变化在3周时出现，表现为牙间乳头大小增加。病变逐渐变得更加严重，在某些情况下，到第6周时牙齿的部分被遮盖。多余的组织显示结缔组织成分增加以及主要为浆细胞的炎性浸润。在有反应的动物中，增生的严重程度各不相同；发生率和严重程度均与血液中环孢素A的浓度有关。在第3、6和10周时，有反应动物的环孢素A平均血药浓度显著高于无反应动物。由于比格犬出现的牙龈增生与人类相似，它们为研究局部和全身因素在牙龈增生诱导中的作用提供了一个极好的模型。
