ADAMTS13：不止是血栓形成的调节因子。
ADAMTS13: more than a regulator of thrombosis.
作者信息
Feng Yun, Li Xueyin, Xiao Juan, Li Wei, Liu Jing, Zeng Xue, Chen Xi, Chen Suhua
机构信息
Department of Obstetrics and Gynaecology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Department of Urology, Zhengzhou First People's Hospital, Zhengzhou, China.
出版信息
Int J Hematol. 2016 Nov;104(5):534-539. doi: 10.1007/s12185-016-2091-2. Epub 2016 Oct 1.
ADAMTS13, a plasma reprolysin-like metalloprotease, proteolyzes von Willebrand factor (VWF). ADAMTS13 is primarily synthesized by hepatic stellate cells (HSCs), and mainly regulates thrombogenesis by cleaving VWF. Recent studies demonstrate that ADAMTS13 also plays a role in the down-regulation of inflammation, regulation angiogenesis, and degradation of extracellular matrix. The purpose of this review is to introduce the state of progress with respect to some of the theorized roles of ADAMTS13.
ADAMTS13是一种血浆类解聚素样金属蛋白酶，可对血管性血友病因子（VWF）进行蛋白水解。ADAMTS13主要由肝星状细胞（HSCs）合成，主要通过裂解VWF来调节血栓形成。最近的研究表明，ADAMTS13在炎症下调、血管生成调节和细胞外基质降解中也发挥作用。本综述的目的是介绍关于ADAMTS13一些理论作用的研究进展情况。
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