维生素D对复发性流产患者外周细胞免疫的调节作用。
Modulatory effects of vitamin D on peripheral cellular immunity in patients with recurrent miscarriage.
作者信息
Chen Xian, Yin Biao, Lian Ruo-Chun, Zhang Tao, Zhang Hong-Zhan, Diao Liang-Hui, Li Yu-Ye, Huang Chun-Yu, Liang De-Sheng, Zeng Yong
机构信息
Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, China.
The State Key Laboratory of Medical Genetics of China, Central South University, Changsha, Hunan, China.
出版信息
Am J Reprod Immunol. 2016 Dec;76(6):432-438. doi: 10.1111/aji.12585. Epub 2016 Oct 1.
PROBLEM
We aimed to investigate the modulatory effects of vitamin D on peripheral blood cellular immune response in patients with recurrent miscarriage (RM).
METHOD OF STUDY
The effect of vitamin D on the number of peripheral blood cells, T helper 1 (Th1) cytokines, and NK cytotoxicity was measured in 99 women with RM.
RESULTS
The percentage of CD19 B cells and NK cytotoxicity at an effector-to-target cell (E:T) ratio of 50:1, 25:1, and 12.5:1 were significantly higher in the vitamin D insufficiency group (VDI) than in the vitamin D normal group (VDN) (P<.05 each). The proportion of TNF-α-expressing Th cells was significantly higher in the vitamin D deficiency group (VDD) than in VDN (P<.05). However, there were no significant differences between VDI and VDD. This dysregulation was significantly reduced with 1,25(OH) D supplementation.
CONCLUSION
The data suggest that the abnormalities of cellular immune response were observed in RM patients with a low vitamin D level, which could be regulated to some extent with 1,25(OH) D supplementation.
问题
我们旨在研究维生素D对复发性流产（RM）患者外周血细胞免疫反应的调节作用。
研究方法
在99例RM女性中检测维生素D对外周血细胞数量、辅助性T细胞1（Th1）细胞因子和自然杀伤细胞（NK）细胞毒性的影响。
结果
维生素D不足组（VDI）中CD19 B细胞百分比以及效应细胞与靶细胞比例（E:T）为50:1、25:1和12.5:1时的NK细胞毒性显著高于维生素D正常组（VDN）（各P<0.05）。维生素D缺乏组（VDD）中表达肿瘤坏死因子-α（TNF-α）的Th细胞比例显著高于VDN（P<0.05）。然而，VDI和VDD之间无显著差异。补充1,25(OH)D后，这种失调显著减轻。
结论
数据表明，维生素D水平低的RM患者存在细胞免疫反应异常，补充1,25(OH)D可在一定程度上对其进行调节。
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