Statache Gianina, Brown Sadaf
Department of Rheumatology, Department of Family Medicine, Abu Dhabi Stem Cell Centre, Abu Dhabi, United Arab Emirates.
Front Reprod Health. 2022 Jun 27;4:936810. doi: 10.3389/frph.2022.936810. eCollection 2022.
Systemic lupus erythematosus patients have long been observed to suffer from vitamin D deficiency. This can be related to either environmental factors, medication, or other comorbidities like renal disease. Moreover, lupus patients have reported conception issues including ovarian failure or recurrent miscarriages. There are vast data regarding vitamin D's ability to support the development of a healthy pregnancy and prevent complications, such as pre-eclampsia and gestational diabetes, likely through its ability to regulate both innate and adaptive immune systems. Although there is an agreement in the medical world that pregnant lupus patients should be screened and receive vitamin D supplements, there are no official guidelines on screening and often the recommended doses are suboptimal. Further research is needed to look at the potential of vitamin supplementation in pregnant lupus patients.
长期以来，人们观察到系统性红斑狼疮患者存在维生素D缺乏的情况。这可能与环境因素、药物治疗或其他合并症（如肾脏疾病）有关。此外，狼疮患者报告了受孕问题，包括卵巢功能衰竭或反复流产。有大量数据表明，维生素D可能通过调节先天和适应性免疫系统，来支持健康怀孕的发展并预防并发症，如先兆子痫和妊娠期糖尿病。尽管医学界一致认为，怀孕的狼疮患者应该接受筛查并补充维生素D，但目前尚无关于筛查的官方指南，而且推荐剂量往往并不理想。需要进一步研究来探讨补充维生素对怀孕狼疮患者的潜在作用。
