Chen Wen-Cheng, Lai Chia-Hsuan, Chuang Huei-Chieh, Lin Paul-Yang, Chen Miao-Fen
Department of Radiation Oncology, Chang Gung Memorial Hospital at Chiayi, Taiwan.
Chang Gung University, College of Medicine, Taiwan.
Head Neck. 2017 Feb;39(2):347-355. doi: 10.1002/hed.24595. Epub 2016 Oct 3.
The purpose of this study was to present our assessment of the significance of myeloid-derived suppressor cells (MDSCs) in head and neck squamous cell carcinoma (HNSCC).
We examined the percentage of MDSCs in the peripheral blood of patients with HNSCC. The relationship among MDSC recruitment, tumor progression, and cyclooxygenase (COX)-2 inhibition was also evaluated by animal models.
Circulating MDSCs were significantly increased in patients with HNSCC compared with healthy people, and this was associated with the clinical tumor burden. In immunocompetent 4-nitroquinoline-1-oxide (4-NQO)-induced oral tumor and immunocompromised tumor implantation animal models, MDSC recruitment was associated with the duration of 4-NQO treatment and tumor progression. The responsible mechanisms included the suppressive ability of T-cell proliferation and augmenting angiogenesis by MDSC. Blockade of COX-2 attenuated the induction and function of MDSCs and subsequently inhibited tumor growth.
The levels of MDSC are linked with tumor progression in HNSCC. Moreover, targeting COX-2 could be a promising strategy for the treatment of HNSCC. © 2016 Wiley Periodicals, Inc. Head Neck 39: 347-355, 2017.
本研究旨在阐述我们对髓系来源抑制细胞（MDSCs）在头颈部鳞状细胞癌（HNSCC）中的意义评估。
我们检测了HNSCC患者外周血中MDSCs的百分比。还通过动物模型评估了MDSC募集、肿瘤进展与环氧合酶（COX）-2抑制之间的关系。
与健康人相比，HNSCC患者循环中的MDSCs显著增加，且这与临床肿瘤负荷相关。在免疫活性4-硝基喹啉-1-氧化物（4-NQO）诱导的口腔肿瘤和免疫缺陷肿瘤植入动物模型中，MDSC募集与4-NQO治疗持续时间及肿瘤进展相关。相关机制包括MDSC对T细胞增殖的抑制能力及促进血管生成。COX-2阻断可减弱MDSCs的诱导和功能，进而抑制肿瘤生长。
MDSC水平与HNSCC中的肿瘤进展相关。此外，靶向COX-2可能是治疗HNSCC的一种有前景的策略。© 2016威利期刊公司。《头颈》39: 347 - 355, 2017。
