Blondin Denis P, Carpentier André C
Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada.
Department of Medicine, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada.
Best Pract Res Clin Endocrinol Metab. 2016 Aug;30(4):497-513. doi: 10.1016/j.beem.2016.09.002. Epub 2016 Sep 12.
The demonstration of the presence of metabolically active brown adipose tissue (BAT) in adult humans using positron emission tomography (PET) over the past decade has lead to the rapid development of our knowledge regarding the role of BAT in energy metabolism in animal models and in humans. Although animal models continue to provide highly valuable information regarding the mechanisms regulating BAT development, mass and metabolic functions, these studies led to many assumptions that have been at best only partially verified in humans so far. Combined to some limitations of the current investigation approaches used in humans, this has lead to speculation on the potential role of BAT dysfunction in the development of cardiometabolic disorders and on the potential of BAT metabolic activation to treat these conditions. Here we propose a critical review of the evidence for the implication of BAT in cardiometabolic health.
在过去十年中，通过正电子发射断层扫描（PET）证实成人中存在代谢活跃的棕色脂肪组织（BAT），这使得我们对BAT在动物模型和人类能量代谢中的作用的认识迅速发展。尽管动物模型继续提供有关调节BAT发育、质量和代谢功能机制的极具价值的信息，但这些研究导致了许多假设，而这些假设迄今为止在人类中充其量只是部分得到验证。再加上目前人类研究方法存在的一些局限性，这引发了关于BAT功能障碍在心脏代谢紊乱发展中的潜在作用以及BAT代谢激活治疗这些疾病的潜力的猜测。在此，我们对BAT与心脏代谢健康相关的证据进行批判性综述。
