Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University ofCampinas (UNICAMP), Campinas, Brazil.
Department of Nutrition, School of Public Health -University of São Paulo, São Paulo, Brazil.
Front Endocrinol (Lausanne). 2022 Jul 19;13:919588. doi: 10.3389/fendo.2022.919588. eCollection 2022.
Brown adipose tissue (BAT) is regarded as an interesting potential target for the treatment of obesity, diabetes, and cardiovascular diseases, and the detailed characterization of its structural and functional phenotype could enable an advance in these fields. Most studies evaluating BAT structure and function were performed in temperate climate regions, and we are yet to know how these findings apply to the 40% of the world's population living in tropical areas. Here, we used F-fluorodeoxyglucose positron emission tomography - magnetic resonance imaging to evaluate BAT in 45 lean, overweight, and obese volunteers living in a tropical area in Southeast Brazil. We aimed at investigating the associations between BAT activity, volume, metabolic activity, and BAT content of triglycerides with adiposity and cardiovascular risk markers in a sample of adults living in a tropical area and we showed that BAT glucose uptake is not correlated with leanness; instead, BAT triglyceride content is correlated with visceral adiposity and markers of cardiovascular risk. This study expands knowledge regarding the structure and function of BAT in people living in tropical areas. In addition, we provide evidence that BAT triglyceride content could be an interesting marker of cardiovascular risk.
棕色脂肪组织（BAT）被认为是治疗肥胖症、糖尿病和心血管疾病的一个有趣的潜在靶点，对其结构和功能表型的详细描述可以推动这些领域的发展。大多数评估 BAT 结构和功能的研究都是在温带气候地区进行的，我们还不知道这些发现如何适用于世界上 40%生活在热带地区的人口。在这里，我们使用 F-氟脱氧葡萄糖正电子发射断层扫描-磁共振成像来评估生活在巴西东南部热带地区的 45 名瘦人、超重者和肥胖者的 BAT。我们的目的是调查在热带地区生活的成年人样本中，BAT 活性、体积、代谢活性和甘油三酯含量与肥胖和心血管风险标志物之间的相关性，结果表明 BAT 的葡萄糖摄取与瘦无关，而 BAT 甘油三酯含量与内脏肥胖和心血管风险标志物相关。本研究扩展了关于生活在热带地区的人群中 BAT 的结构和功能的知识。此外，我们提供的证据表明 BAT 甘油三酯含量可能是心血管风险的一个有趣标志物。
