Efe Tolga Han, Gayretli Yayla Kadriye, Yayla Cagri, Ertem Ahmet Goktug, Cimen Tolga, Erken Pamukcu Hilal, Bilgin Murat, Erat Mehmet, Dogan Mehmet, Yeter Ekrem
Department of Cardiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Department of Cardiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Rev Port Cardiol. 2016 Nov;35(11):573-578. doi: 10.1016/j.repc.2016.06.008. Epub 2016 Oct 1.
Calcific aortic valve disease, a chronic progressive disorder, is the leading cause of valve replacement among elderly patients. The lymphocyte/monocyte ratio has been recently put forward as an inflammatory marker of relevance in several cancers as well as in cardiovascular disease. This study aims to assess the correlation between severity of calcific aortic stenosis and the lymphocyte/monocyte ratio.
The study retrospectively included 178 patients with a diagnosis of calcific aortic stenosis and 139 age- and gender-matched controls. The patients were divided into two groups according to the severity of aortic stenosis: mild-to-moderate and severe.
An inverse correlation was discerned between the severity of the aortic stenosis process (mean gradient) and the lymphocyte/monocyte ratio (r=-0.232, p=0.002). The lymphocyte/monocyte ratio was observed to decrease as the severity of aortic stenosis increased (p<0.001) in the group with severe aortic stenosis compared with the mild-to-moderate aortic stenosis and control groups (p<0.001, p=0.005 respectively), and in the group with mild-to-moderate aortic stenosis compared with the control group (p=0.003). Multivariate regression analysis revealed that the lymphocyte/monocyte ratio was independently related to the severity of calcific aortic stenosis (p=0.003).
The present study demonstrated the existence of a statistically significant inverse relationship between severity of calcific aortic stenosis and the lymphocyte/monocyte ratio. The study also revealed that the lymphocyte/monocyte ratio was significantly related to the severity of the aortic valve stenosis process.
钙化性主动脉瓣疾病是一种慢性进行性疾病，是老年患者瓣膜置换的主要原因。淋巴细胞/单核细胞比率最近被提出作为在几种癌症以及心血管疾病中具有相关性的炎症标志物。本研究旨在评估钙化性主动脉瓣狭窄的严重程度与淋巴细胞/单核细胞比率之间的相关性。
本研究回顾性纳入了178例诊断为钙化性主动脉瓣狭窄的患者以及139例年龄和性别匹配的对照组。根据主动脉瓣狭窄的严重程度将患者分为两组：轻度至中度和重度。
在主动脉瓣狭窄程度（平均压差）与淋巴细胞/单核细胞比率之间发现了负相关（r = -0.232，p = 0.002）。与轻度至中度主动脉瓣狭窄组和对照组相比（分别为p <0.001，p = 0.005），在重度主动脉瓣狭窄组中，随着主动脉瓣狭窄严重程度的增加，淋巴细胞/单核细胞比率降低（p <0.001）；与对照组相比，在轻度至中度主动脉瓣狭窄组中淋巴细胞/单核细胞比率也降低（p = 0.003）。多因素回归分析显示，淋巴细胞/单核细胞比率与钙化性主动脉瓣狭窄的严重程度独立相关（p = 0.003）。
本研究表明钙化性主动脉瓣狭窄的严重程度与淋巴细胞/单核细胞比率之间存在统计学上显著的负相关关系。该研究还表明，淋巴细胞/单核细胞比率与主动脉瓣狭窄程度显著相关。
