Department of Cardiovascular Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, No. 324 Jingwu Road, Jinan, Shandong 250021, China.
Department of Cardiovascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, Shandong 250021, China.
Biomark Med. 2020 Oct;14(14):1329-1339. doi: 10.2217/bmm-2020-0228. Epub 2020 Oct 16.
This study examined the role of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, in predicting the severity of calcific aortic valve stenosis (CAVS) in a Chinese case-control study. The LMR significantly decreased in the patients with CAVS compared with healthy controls. An inverse correlation was observed between the severity of stenosis and LMR in the patients. Additionally, the LMR was identified in the multivariate analysis as an independent predictor of severe CAVS. This study provides evidence of an inverse correlation between the severity of CAVS and LMR. LMR could potentially be applied as an independent predictor of severe CAVS and could be incorporated into a novel predictive model.
本研究通过一项中国病例对照研究，探讨了淋巴细胞与单核细胞比值（LMR）这一炎症生物标志物在预测钙化性主动脉瓣狭窄（CAVS）严重程度中的作用。与健康对照组相比，CAVS 患者的 LMR 显著降低。此外，在多变量分析中，LMR 被确定为严重 CAVS 的独立预测因子。本研究提供了 CAVS 严重程度与 LMR 呈负相关的证据。LMR 可能作为严重 CAVS 的独立预测因子，并可纳入新的预测模型。
