Akdag Serkan, Akyol Aytac, Asker Muntecep, Duz Ramazan, Gumrukcuoglu Hasan Ali
Department of Cardiology, Yuzuncu Yil University Medical Faculty, Van, Turkey.
Med Sci Monit. 2015 Nov 6;21:3395-400. doi: 10.12659/msm.894774.
Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory indicator which is closely associated with adverse cardiovascular events. Therefore, we aimed to investigate the relationship between PLR and the severity of calcific aortic stenosis (AS).
The study was designed as a retrospective study. A total of 86 consecutive patients with calcific AS were divided into two groups as mild-to-moderate AS and severe AS according to the transaortic mean pressure gradient. PLR levels were calculated from the complete blood count (CBC).
Platelet to lymphocyte ratio was significantly higher in severe and mild-to-moderate AS groups when compared to the control subjects (151±31.2, p<0.001, 138±28.8 vs. 126±26.5, p=0.008, respectively). In the subgroup analysis of AS patients, PLR was found to be higher in the severe AS group compared to mild-to-moderate group (p<0.001). A significant correlation was found between PLR and transaortic mean pressure gradient in patients with AS (r=0.421, p<0.001).
Our study results demonstrated that increased PLR correlates with the severity of calcific AS.
血小板与淋巴细胞比值（PLR）是一种新兴的炎症指标，与不良心血管事件密切相关。因此，我们旨在研究PLR与钙化性主动脉瓣狭窄（AS）严重程度之间的关系。
本研究设计为一项回顾性研究。根据经主动脉平均压力梯度，将86例连续的钙化性AS患者分为轻度至中度AS组和重度AS组。PLR水平通过全血细胞计数（CBC）计算得出。
与对照组相比，重度和轻度至中度AS组的血小板与淋巴细胞比值显著更高（分别为151±31.2，p<0.001；138±28.8与126±26.5，p=0.008）。在AS患者的亚组分析中，发现重度AS组的PLR高于轻度至中度组（p<0.001）。AS患者的PLR与经主动脉平均压力梯度之间存在显著相关性（r=0.421，p<0.001）。
我们的研究结果表明，PLR升高与钙化性AS的严重程度相关。
