酒精相关癌症与RNA聚合酶III基因的失调
Alcohol-associated cancer and deregulation of Pol III genes.
作者信息
Shi Ganggang, Zhong Shuping
机构信息
Shantou University Medical College, Shantou, Guangdong Province, China.
Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
Gene. 2017 May 15;612:25-28. doi: 10.1016/j.gene.2016.09.046. Epub 2016 Sep 30.
Abstract
Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism of alcohol-promoted cell transformation and tumor development. Alcohol induces JNK1 activation and increases cellular levels of c-Jun to upregulate Brf1 expression and Pol III gene transcription, leading to an enhancement of rates of cell transformation and tumor formation.
摘要
新出现的证据表明，饮酒与人体不同器官的癌症有关。然而，酒精相关人类癌症的分子机制仍有待阐明。在此，本文旨在阐明酒精促进细胞转化和肿瘤发展的新机制。酒精诱导JNK1激活并增加c-Jun的细胞水平，以上调Brf1表达和Pol III基因转录，从而提高细胞转化和肿瘤形成的速率。
相似文献
1
Alcohol-associated cancer and deregulation of Pol III genes.
Gene. 2017 May 15;612:25-28. doi: 10.1016/j.gene.2016.09.046. Epub 2016 Sep 30.
2
Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells.
Gene. 2017 Aug 30;626:309-318. doi: 10.1016/j.gene.2017.05.048. Epub 2017 May 25.
3
ERα mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.
Carcinogenesis. 2013 Jan;34(1):28-37. doi: 10.1093/carcin/bgs316. Epub 2012 Oct 10.
4
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
Oncotarget. 2014 Dec 15;5(23):12410-7. doi: 10.18632/oncotarget.2678.
5
The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.
Chem Biol Interact. 2020 May 25;323:109057. doi: 10.1016/j.cbi.2020.109057. Epub 2020 Mar 18.
6
Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression.
J Biol Chem. 2011 Jan 28;286(4):2393-401. doi: 10.1074/jbc.M110.192955. Epub 2010 Nov 24.
7
Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation.
Carcinogenesis. 2013 Nov;34(11):2460-9. doi: 10.1093/carcin/bgt219. Epub 2013 Jun 17.
8
Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes.
Gene. 2013 Aug 15;526(1):54-60. doi: 10.1016/j.gene.2013.02.004. Epub 2013 Feb 20.
9
Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration.
Oxid Med Cell Longev. 2020 Jun 27;2020:2067959. doi: 10.1155/2020/2067959. eCollection 2020.
10
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.
Gene. 2015 Feb 1;556(1):74-9. doi: 10.1016/j.gene.2014.11.009. Epub 2014 Nov 8.
引用本文的文献
1
Nitrate ameliorates alcohol-induced cognitive impairment via oral microbiota.
J Neuroinflammation. 2025 Apr 15;22(1):106. doi: 10.1186/s12974-025-03439-x.
2
Huangqin-Huanglian Decoction Protects Liver against Non-alcoholic Fatty Liver Disease in High Fat-diet Mice.
Endocr Metab Immune Disord Drug Targets. 2024;24(6):691-708. doi: 10.2174/0118715303257018230927182802.
3
ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes.
Oxid Med Cell Longev. 2021 Oct 4;2021:5888432. doi: 10.1155/2021/5888432. eCollection 2021.
4
Exploring the Role and Mechanism of pAMPK-Mediated Dysregulation of Brf1 and RNA Pol III Genes.
Oxid Med Cell Longev. 2021 Apr 20;2021:5554932. doi: 10.1155/2021/5554932. eCollection 2021.
5
Mitogen- and Stress-Activated Protein Kinase 1 Mediates Alcohol-Upregulated Transcription of Brf1 and tRNA Genes to Cause Phenotypic Alteration.
Oxid Med Cell Longev. 2020 Jun 27;2020:2067959. doi: 10.1155/2020/2067959. eCollection 2020.
6
Longitudinal gut microbiome changes in alcohol use disorder are influenced by abstinence and drinking quantity.
Gut Microbes. 2020 Nov 1;11(6):1608-1631. doi: 10.1080/19490976.2020.1758010.
7
Role of betaine in inhibiting the induction of RNA Pol III gene transcription and cell growth caused by alcohol.
Chem Biol Interact. 2020 Jul 1;325:109129. doi: 10.1016/j.cbi.2020.109129. Epub 2020 May 11.
8
The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.
Chem Biol Interact. 2020 May 25;323:109057. doi: 10.1016/j.cbi.2020.109057. Epub 2020 Mar 18.
9
Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer.
Oxid Med Cell Longev. 2019 Oct 31;2019:4818106. doi: 10.1155/2019/4818106. eCollection 2019.
10
Effects on prostate cancer cells of targeting RNA polymerase III.
Nucleic Acids Res. 2019 May 7;47(8):3937-3956. doi: 10.1093/nar/gkz128.
本文引用的文献
1
The significance of Brf1 overexpression in human hepatocellular carcinoma.
Oncotarget. 2016 Feb 2;7(5):6243-54. doi: 10.18632/oncotarget.6668.
2
Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.
Oncotarget. 2014 Dec 15;5(23):12410-7. doi: 10.18632/oncotarget.2678.
3
Recent evidence on alcohol and cancer epidemiology.
Future Oncol. 2013 Sep;9(9):1315-22. doi: 10.2217/fon.13.94.
4
ERα mediates alcohol-induced deregulation of Pol III genes in breast cancer cells.
Carcinogenesis. 2013 Jan;34(1):28-37. doi: 10.1093/carcin/bgs316. Epub 2012 Oct 10.
5
Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1.
Breast Cancer Res Treat. 2012 Jun;133(3):1037-48. doi: 10.1007/s10549-011-1902-7. Epub 2011 Dec 9.
6
Preventable exposures associated with human cancers.
J Natl Cancer Inst. 2011 Dec 21;103(24):1827-39. doi: 10.1093/jnci/djr483. Epub 2011 Dec 12.
7
Alcohol promotes mammary tumor development via the estrogen pathway in estrogen receptor alpha-negative HER2/neu mice.
Alcohol Clin Exp Res. 2012 Apr;36(4):577-87. doi: 10.1111/j.1530-0277.2011.01654.x. Epub 2011 Oct 7.
8
Phosphorylation of histone H3 serine 28 modulates RNA polymerase III-dependent transcription.
Oncogene. 2011 Sep 15;30(37):3943-52. doi: 10.1038/onc.2011.105. Epub 2011 Apr 4.
9
Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression.
J Biol Chem. 2011 Jan 28;286(4):2393-401. doi: 10.1074/jbc.M110.192955. Epub 2010 Nov 24.
10
The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12682-7. doi: 10.1073/pnas.0904843106. Epub 2009 Jul 20.
Zotero 插件