Meyer Jacob D, Koltyn Kelli F, Stegner Aaron J, Kim Jee-Seon, Cook Dane B
Department of Kinesiology, University of Wisconsin-Madison, 2000 Observatory Drive, Madison, WI 53706, USA.
Department of Kinesiology, University of Wisconsin-Madison, 2000 Observatory Drive, Madison, WI 53706, USA.
Psychoneuroendocrinology. 2016 Dec;74:286-294. doi: 10.1016/j.psyneuen.2016.09.022. Epub 2016 Sep 28.
Brain-derived neurotrophic factor (BDNF) has recently emerged as one potential mechanism with which exercise improves mood in major depressive disorder (MDD). This study examined the relationship between changes in serum total BDNF and mood following acute exercise in MDD. It was hypothesized that acute exercise would increase BDNF in an intensity-dependent manner and that changes in BDNF would be significantly related to improvement in depressed mood post-exercise.
Twenty-four women (age: 38.6±14.0years) with MDD exercised for 30min on a stationary bicycle at light, moderate and hard exercise intensities and performed a quiet rest session using a within-subjects, randomized and counter-balanced design. Before, 10 and 30min after each session, participants completed the profile of mood states (POMS). Blood was drawn before and within 10min after completion of each session and serum total BDNF (sBDNF) was measured by enzyme-linked immunosorbent assay. Acute exercise-induced changes in POMS Depression and sBDNF were analyzed via 4 session (quiet rest, light, moderate, hard) by 2 measurement (pre, post) ANOVA. Secondary analyses examined the effects of baseline mood and antidepressant usage on sBDNF.
Exercise resulted in an acute improvement in depressed mood that was not intensity dependent (p>0.05), resulting in significant acute increases in sBDNF (p=0.006) that were also not intensity-dependent (p>0.05). Acute changes in sBDNF were not significantly correlated to changes in POMS depression at 10m (r=-0.171, p=0.161) or 30m (r=-0.151, p=0.215) post-exercise. The fourteen participants taking antidepressant medications exhibited lower post-exercise sBDNF (p=0.015) than the participants not currently taking antidepressants, although mood responses were similar.
Acute exercise is an effective mood-enhancing stimulus, although sBDNF does not appear to play a role in this short-term response. Patients who are not currently taking antidepressant medications and those who have greater pre-exercise depression may experience a greater sBDNF response to exercise, but the clinical significance of this is currently unclear. Circulating BDNF levels are unlikely to be altered by steady-state acute exercise in a linear dose-dependent manner. This does not eliminate its potential relevance in the antidepressant response to chronic exercise training, but suggests that other mechanisms are involved in the acute affective response to exercise in depression.
脑源性神经营养因子（BDNF）最近已成为运动改善重度抑郁症（MDD）患者情绪的一种潜在机制。本研究探讨了MDD患者急性运动后血清总BDNF变化与情绪之间的关系。研究假设急性运动将以强度依赖的方式增加BDNF，并且BDNF的变化将与运动后抑郁情绪的改善显著相关。
24名患有MDD的女性（年龄：38.6±14.0岁）在固定自行车上以轻度、中度和重度运动强度进行30分钟的运动，并采用受试者内随机和平衡设计进行安静休息时段。在每个时段之前、之后10分钟和30分钟，参与者完成情绪状态量表（POMS）。在每个时段结束前和结束后10分钟内采集血液，通过酶联免疫吸附测定法测量血清总BDNF（sBDNF）。通过4个时段（安静休息、轻度、中度、重度）×2次测量（运动前、运动后）的方差分析来分析急性运动引起的POMS抑郁和sBDNF的变化。二级分析研究了基线情绪和抗抑郁药物使用对sBDNF的影响。
运动导致抑郁情绪急性改善，且不依赖于运动强度（p>0.05），同时导致sBDNF显著急性升高（p=0.006），这也不依赖于运动强度（p>0.05）。运动后10分钟（r=-0.171，p=0.161）或30分钟（r=-0.151，p=0.215）时，sBDNF的急性变化与POMS抑郁的变化无显著相关性。与目前未服用抗抑郁药物的参与者相比，14名服用抗抑郁药物的参与者运动后的sBDNF较低（p=0.015），尽管情绪反应相似。
急性运动是一种有效的情绪增强刺激，尽管sBDNF似乎在这种短期反应中不起作用。目前未服用抗抑郁药物的患者以及运动前抑郁程度较高的患者可能对运动有更大的sBDNF反应，但其临床意义目前尚不清楚。稳态急性运动不太可能以线性剂量依赖的方式改变循环BDNF水平。这并没有消除其在慢性运动训练抗抑郁反应中的潜在相关性，但表明在抑郁症患者对运动的急性情感反应中涉及其他机制。
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