Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Geriatrics, Krankenhaus Königin Elisabeth Herzberge, Berlin, Germany.
Social and Preventive Medicine, University of Potsdam, Potsdam, Germany.
Psychoneuroendocrinology. 2019 Apr;102:212-215. doi: 10.1016/j.psyneuen.2018.12.015. Epub 2018 Dec 14.
Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p < .001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p = .001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus, findings of this study suggest an involvement of peripheral as well as additional - possibly brain-derived - mechanisms explaining exercise-related BDNF release in MDD. For future studies in the field of exercise-related BDNF research, the importance of controlling for peripheral parameters is emphasized.
生理机制的抗抑郁作用的体育锻炼在重性抑郁障碍 (MDD) 似乎涉及改变脑源性神经营养因子 (BDNF) 水平。然而，以前的研究调查了这一效果在单一回合的运动，并没有控制混杂的外周因素导致 BDNF 的改变。因此，运动诱导的 BDNF 变化的根本原因仍不清楚。本研究旨在探讨血清脑源性神经营养因子 (sBDNF) 的变化由于一个单一回合的分级有氧运动在一组 30 例门诊患者与 MDD，表明更精确的分析方法考虑到血浆容量的转移和血小板的数量。结果表明，运动诱导的 sBDNF 增加仍然显著（p <.001）时调整血浆容量的转移和控制血小板的数量。sBDNF 变化和血小板的相互作用也是显著的（p =.001）表明更大的 sBDNF 增加在参与者的血小板数量较少。因此，本研究的结果表明，外周机制以及额外的 - 可能是大脑衍生的 - 机制参与解释运动相关的 BDNF 释放与 MDD。为了在运动相关的 BDNF 研究领域的未来研究，强调控制外周参数的重要性。
