Takahashi Masaki, Lim Pei Jean, Tsubosaka Miku, Kim Hyeon-Ki, Miyashita Masashi, Suzuki Katsuhiko, Tan Eng Lee, Shibata Shigenobu
Waseda Bioscience Research Institute in Singapore, Waseda University: 138667, Singapore.
Graduate School of Advanced Science and Engineering, Waseda University, Japan.
J Phys Ther Sci. 2019 Apr;31(4):408-413. doi: 10.1589/jpts.31.408. Epub 2019 Apr 1.
[Purpose] Little is known about the effectiveness of daily physical activity on depression biomarkers in older adults. This study aimed to investigate the effects of increased daily physical activity for 8 weeks on depression biomarkers in postmenopausal women. [Participants and Methods] Thirty-eight postmenopausal females were randomly assigned into a control or an active group and were asked to wear a uniaxial accelerometer for 8 weeks. Blood samples were obtained at baseline and at the end of the intervention. During the intervention, the active group was asked to increase their physical activity level above their usual lifestyle whereas those in the control group maintained their daily lifestyle. [Results] After the 8-week intervention, the step counts of the participants in the active group increased. The serum concentration of the brain-derived neurotrophic factor and serotonin increased significantly in the active group, but not in the control group, as compared with baseline values. The serum concentration of derivatives of reactive oxygen metabolites and biological antioxidant potential did not change after the intervention in either group. [Conclusion] These findings may suggest that promotion of daily physical activity in postmenopausal women has a positive impact on depression without any change in oxidative stress.
[目的] 关于日常体育活动对老年人抑郁生物标志物的有效性知之甚少。本研究旨在调查绝经后女性每日增加体育活动8周对抑郁生物标志物的影响。[参与者与方法] 38名绝经后女性被随机分为对照组或运动组，并被要求佩戴单轴加速度计8周。在基线期和干预结束时采集血样。在干预期间，运动组被要求将其身体活动水平提高到高于其平常的生活方式，而对照组则维持其日常生活方式。[结果] 经过8周的干预，运动组参与者的步数增加。与基线值相比，运动组脑源性神经营养因子和血清素的血清浓度显著增加，而对照组未增加。两组干预后活性氧代谢产物衍生物的血清浓度和生物抗氧化能力均未改变。[结论] 这些发现可能表明，促进绝经后女性的日常体育活动对抑郁有积极影响，而氧化应激无任何变化。
