Burucoa C, Mura P, Robert R, Boinot C, Bouquet S, Piriou A
Laboratoire de Biochimie et de Toxicologie, Hôpital La Milétrie, Poitiers.
J Toxicol Clin Toxicol. 1989;27(1-2):79-89. doi: 10.3109/15563658909038571.
Plasma chlorophacinone determinations were performed in three cases of intoxication. The data collected in this study confirm the particularly prolonged anticoagulant effect of this compound and show that the knowledge of plasma concentrations may be very useful for clinicians since it allows to confirm the diagnosis and to evaluate the duration of the treatment. The determination of half-lives was investigated and the results indicate that the greater the quantity absorbed, the longer the half-life. The effect of phenobarbital on the elimination of cholorophacinone could be studied in one case. An increased elimination was noted when phenobarbital was administered.
对3例中毒患者进行了血浆氯鼠酮测定。本研究收集的数据证实了该化合物特别长的抗凝作用，并表明血浆浓度的知识对临床医生可能非常有用，因为它有助于确诊并评估治疗持续时间。研究了半衰期的测定，结果表明吸收量越大，半衰期越长。在1例患者中研究了苯巴比妥对氯鼠酮消除的影响。给予苯巴比妥后，观察到消除增加。
