Chen J Y, Tsai W Y
Gaoxiong Yi Xue Ke Xue Za Zhi. 1989 Apr;5(4):206-11.
The interactions of beta-cyclodextrin (beta-CD) with three sulfonamide drugs were studied. Observations were made on the effects of beta-CD on the solubility and the dissolution rate of these drugs in aqueous solution when comparing two different methods. The solubility of these three drugs was found to increase with the addition of beta-CD. This increase in solubility when using beta-CD was considered to be due to the formation of inclusion compounds. The dissolution rate of drugs increased with beta-CD, and was similar in tendency to the solubility data. These effects on both solubility and dissolution rates were similar regardless of which method was used. The X-ray diffraction pattern of the drug/beta-CD freeze-drying powder showed a clear difference from the physical mixture of intact drugs.
研究了β-环糊精（β-CD）与三种磺胺类药物的相互作用。在比较两种不同方法时，观察了β-CD对这些药物在水溶液中的溶解度和溶解速率的影响。发现添加β-CD后这三种药物的溶解度增加。使用β-CD时溶解度的增加被认为是由于形成了包合物。药物的溶解速率随β-CD增加，且趋势与溶解度数据相似。无论使用哪种方法，对溶解度和溶解速率的这些影响都是相似的。药物/β-CD冷冻干燥粉末的X射线衍射图谱与完整药物的物理混合物有明显差异。
