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Tamoxifen metabolism in breast cancer treatment: Taking the focus off the CYP2D6 gene.

作者信息

Novillo A, Romero-Lorca A, Gaibar M, Rubio M, Fernández-Santander A

机构信息

Department of Basic Biomedical Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain.

出版信息

Pharmacogenomics J. 2017 Mar;17(2):109-111. doi: 10.1038/tpj.2016.73. Epub 2016 Oct 4.

DOI:10.1038/tpj.2016.73
PMID:27698402
Abstract
摘要

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本文引用的文献

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Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients.UGT1A4、UGT2B7和UGT2B15的药物遗传学及其对亚洲乳腺癌患者他莫昔芬处置的影响。
Clin Pharmacokinet. 2016 Oct;55(10):1239-1250. doi: 10.1007/s40262-016-0402-7.
2
Pharmacogenetics of CYP2D6 and tamoxifen therapy: Light at the end of the tunnel?CYP2D6 基因与他莫昔芬治疗的药物遗传学:隧道尽头的曙光?
Pharmacol Res. 2016 May;107:398-406. doi: 10.1016/j.phrs.2016.03.025. Epub 2016 Apr 8.
3
Dose Escalation of Tamoxifen in Patients with Low Endoxifen Level: Evidence for Therapeutic Drug Monitoring-The TADE Study.
Onco Targets Ther. 2017 Nov 13;10:5429-5437. doi: 10.2147/OTT.S149197. eCollection 2017.
他莫昔芬在低内消旋体雌二醇水平患者中的剂量递增:治疗药物监测的证据——TADE 研究。
Clin Cancer Res. 2016 Jul 1;22(13):3164-71. doi: 10.1158/1078-0432.CCR-15-1470. Epub 2016 Feb 4.
4
Contribution of ABCB1 and CYP2D6 genotypes to the outcome of tamoxifen adjuvant treatment in premenopausal women with breast cancer.ABCB1和CYP2D6基因分型对绝经前乳腺癌女性他莫昔芬辅助治疗结果的影响
Physiol Res. 2015;64(Suppl 4):S539-47. doi: 10.33549/physiolres.933234.
5
Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients.葡萄糖醛酸酶基因UGT1A4、UGT2B7、UGT2B15和UGT2B17对乳腺癌患者他莫昔芬代谢的影响。
PLoS One. 2015 Jul 15;10(7):e0132269. doi: 10.1371/journal.pone.0132269. eCollection 2015.
6
Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.药物遗传学对他莫昔芬药代动力学和药效学的影响。
Clin Pharmacokinet. 2015 Aug;54(8):797-810. doi: 10.1007/s40262-015-0273-3.
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Individualization of tamoxifen therapy: much more than just CYP2D6 genotyping.个体化他莫昔芬治疗:不仅仅是 CYP2D6 基因分型。
Cancer Treat Rev. 2015 Mar;41(3):289-99. doi: 10.1016/j.ctrv.2015.01.002. Epub 2015 Jan 14.
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PLoS One. 2013 Jul 29;8(7):e70183. doi: 10.1371/journal.pone.0070183. Print 2013.
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Breast Cancer Res Treat. 2013 May;139(1):95-105. doi: 10.1007/s10549-013-2511-4. Epub 2013 Apr 12.