精子发生过程中的DNA甲基化与男性不育
DNA methylation in spermatogenesis and male infertility.
作者信息
Cui Xiangrong, Jing Xuan, Wu Xueqing, Yan Meiqin, Li Qiang, Shen Yan, Wang Zhenqiang
机构信息
Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China; Division of Clinical Microbiology The Center Hospital of Linfen, Linfen, Shanxi 041000, P.R. China.
Clinical Laboratory, Shanxi Province People's Hospital, Taiyuan, Shanxi 030001, P.R. China.
出版信息
Exp Ther Med. 2016 Oct;12(4):1973-1979. doi: 10.3892/etm.2016.3569. Epub 2016 Aug 4.
Infertility is a significant problem for human reproduction, with males and females equally affected. However, the molecular mechanisms underlying male infertility remain unclear. Spermatogenesis is a highly complex process involving mitotic cell division, meiosis cell division and spermiogenesis; during this period, unique and extensive chromatin and epigenetic modifications occur to bring about specific epigenetic profiles in spermatozoa. It has recently been suggested that the dysregulation of epigenetic modifications, in particular the methylation of sperm genomic DNA, may serve an important role in the development of numerous diseases. The present study is a comprehensive review on the topic of male infertility, aiming to elucidate the association between sperm genomic DNA methylation and poor semen quality in male infertility. In addition, the current status of the genetic and epigenetic determinants of spermatogenesis in humans is discussed.
不孕症是人类生殖中的一个重大问题，男性和女性受影响程度相当。然而，男性不育的分子机制仍不清楚。精子发生是一个高度复杂的过程，涉及有丝分裂细胞分裂、减数分裂细胞分裂和精子形成；在此期间，会发生独特而广泛的染色质和表观遗传修饰，以在精子中产生特定的表观遗传特征。最近有人提出，表观遗传修饰的失调，特别是精子基因组DNA的甲基化，可能在多种疾病的发生中起重要作用。本研究是关于男性不育主题的全面综述，旨在阐明男性不育中精子基因组DNA甲基化与精液质量差之间的关联。此外，还讨论了人类精子发生的遗传和表观遗传决定因素的现状。
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