Hoellen Friederike, Waldmann Annika, Banz-Jansen Constanze, Rody Achim, Heide Maria, Köster Frank, Ribbat-Idel Julika, Thorns Christoph, Gebhard Maximilian, Oberländer Martina, Habermann Jens K, Thill Marc
Department of Gynecology and Obstetrics, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck Campus, Lübeck D-23538, Germany.
Institute for Social Medicine and Epidemiology, University of Lübeck, Lübeck D-23538, Germany.
Oncol Lett. 2016 Oct;12(4):2351-2356. doi: 10.3892/ol.2016.4925. Epub 2016 Jul 29.
Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.
环氧化酶-2（COX-2）与癌症发生及肿瘤进展相关。本研究分析了COX-2表达在浸润性宫颈鳞状细胞癌患者中的作用。收集了123例宫颈癌患者的组织样本，采用抗COX-2抗体进行免疫组织化学（IHC）回顾性分析。分析了患者的临床和生存数据。28例患者（23%）检测到COX-2阳性染色（定义为免疫反应评分≥4），肿瘤细胞中的染色百分比显著高于瘤周基质细胞（P<0.001）。COX-2表达与淋巴管间隙浸润（LVSI；P=0.017）显著相关。COX-2表达与LVSI的关联提示COX-2可能对宫颈癌的肿瘤进展有影响。需要进一步开展包括更大患者群体的研究，以便对临床亚组和患者生存进行分析。
