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作为三阴性乳腺癌患者生存的独立预后因素，治疗前甘油三酯/高密度脂蛋白胆固醇比值优于甘油三酯水平。

Pretreatment TG/HDL-C Ratio Is Superior to Triacylglycerol Level as an Independent Prognostic Factor for the Survival of Triple Negative Breast Cancer Patients.

作者信息

Dai Danian, Chen Bo, Wang Bin, Tang Hailin, Li Xing, Zhao Zhiping, Li Xuan, Xie Xiaoming, Wei Weidong

机构信息

Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Institute of Life Science, Chongqing Medical University, Chongqing, China.

出版信息

J Cancer. 2016 Aug 7;7(12):1747-1754. doi: 10.7150/jca.15776. eCollection 2016.

DOI:10.7150/jca.15776
PMID:27698913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5039397/
Abstract

PURPOSE

Previous studies have reported that the triacylglycerol (TG) level and high-density lipoprotein cholesterol (HDL-C) are connected with breast cancer. However, the prognostic utility of the TG level and the TG/HDL-C ratio (THR) as conventional biomarkers in patients with triple negative breast cancer (TNBC) has not been elucidated. In this research, we investigate and compare the predictive value of the pretreatment serum TG level and THR in TNBC patients.

METHODS

We evaluated 221 patients with TNBC who had pretreatment conventional blood biochemical examinations and calculated the THR. Univariate and multivariate logistic regression analyses were used to assess the effect of the TG level and the THR on overall survival (OS) and disease-free survival (DFS).

RESULTS

The optimal cutoff values of the TG level and the THR were determined to be 0.935 mmol/L and 0.600, respectively. As shown in a Kaplan-Meier analysis, TNBC patients with a high TG level and THR had shorter OS and DFS than patients in the low-level groups ( < 0.05). The multivariate analysis suggested that the pretreatment THR level is an independent prognostic factor of OS (HR: 1.935; 95%CI: 1.032-3.629; = 0.040) in TNBC patients.

CONCLUSIONS

In conclusion, our data indicate that a high THR is an independent predictor and is superior to the TG level for predicting poor clinical outcomes in TNBC patients.

摘要

目的

既往研究报道三酰甘油（TG）水平和高密度脂蛋白胆固醇（HDL-C）与乳腺癌有关。然而，TG水平和TG/HDL-C比值（THR）作为三阴性乳腺癌（TNBC）患者常规生物标志物的预后效用尚未阐明。在本研究中，我们调查并比较了TNBC患者治疗前血清TG水平和THR的预测价值。

方法

我们评估了221例接受治疗前常规血液生化检查的TNBC患者，并计算了THR。采用单因素和多因素逻辑回归分析来评估TG水平和THR对总生存期（OS）和无病生存期（DFS）的影响。

结果

TG水平和THR的最佳截断值分别确定为0.935 mmol/L和0.600。如Kaplan-Meier分析所示，TG水平和THR高的TNBC患者的OS和DFS比低水平组患者短（P<0.05）。多因素分析表明，治疗前THR水平是TNBC患者OS的独立预后因素（HR：1.935；95%CI：1.032-3.629；P = 0.040）。

结论

总之，我们的数据表明，高THR是TNBC患者不良临床结局的独立预测指标，且在预测方面优于TG水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdc/5039397/9724ea0b9c6c/jcav07p1747g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdc/5039397/8f881acb6a83/jcav07p1747g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdc/5039397/46e3aed9138b/jcav07p1747g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdc/5039397/9724ea0b9c6c/jcav07p1747g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdc/5039397/8f881acb6a83/jcav07p1747g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdc/5039397/46e3aed9138b/jcav07p1747g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cdc/5039397/9724ea0b9c6c/jcav07p1747g003.jpg

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