Catteau Xavier, Simon Philippe, Buxant Frédéric, Noël Jean-Christophe
Department of Pathology, Tivoli University Hospital-Free University of Brussels, La Louvière, Belgium; Department of Pathology, Erasme University Hospital-Free University of Brussels, Brussels, Belgium; Institute of Pathology and Genetics, Gosselies, Belgium.
Department of Pathology, Erasme University Hospital-Free University of Brussels, Brussels, Belgium; Gynaecology Unit, Erasme University Hospital-Free University of Brussels, Brussels, Belgium.
Mol Clin Oncol. 2016 Oct;5(4):372-376. doi: 10.3892/mco.2016.975. Epub 2016 Aug 4.
Cancer- associated fibroblasts (CAFs) are actively involved in breast carcinoma. Our previous study demonstrated that the majority of these CAFs were smooth muscle actin (SMA) positive and were therefore termed peritumoral myofibroblast (PMY). Glucocorticoid, linked or not with its receptor (GR), has been postulated to serve a major role in normal breast and breast carcinoma; however, their role in CAFs remains poorly understood. The aim of the present study was to assess the presence of GR in breast CAFs and particularly in PMY in 56 cases of invasive breast carcinoma in correlation with clinicopathological parameters, by immunohistochemistry. GR was observed in CAFs in 51 cases (91%) and were more frequent in luminal A subtype (19/19 cases; 100%). The stromal expression was statistically correlated with the tumor grade (P=0.03), the Ki-67 index (P=0.003) and the presence of GR in the epithelial component (P=0.01). The demonstration of a frequent expression of GR in breast CAFs may serve as an interesting target for future therapeutics for the regulation of the tumoral breast microenvironment.
癌症相关成纤维细胞（CAFs）积极参与乳腺癌的发生发展。我们之前的研究表明，这些CAFs中的大多数平滑肌肌动蛋白（SMA）呈阳性，因此被称为肿瘤周围肌成纤维细胞（PMY）。糖皮质激素，无论是否与其受体（GR）结合，都被认为在正常乳腺和乳腺癌中起主要作用；然而，它们在CAFs中的作用仍知之甚少。本研究的目的是通过免疫组织化学方法，评估56例浸润性乳腺癌中GR在乳腺CAFs尤其是PMY中的表达情况，并与临床病理参数进行相关性分析。在51例（91%）的CAFs中观察到GR表达，且在腔面A型亚型中更为常见（19/19例；100%）。基质表达与肿瘤分级（P=0.03）、Ki-67指数（P=0.003）以及上皮成分中GR的表达（P=0.01）在统计学上具有相关性。乳腺CAFs中GR频繁表达的证实可能为未来调控肿瘤性乳腺微环境的治疗提供一个有趣的靶点。
