Gupta Sunjai, Anderson Robert, Holt Richard Ig
Institute of Psychiatry, Psychology and Neurology, Kings College, De Crespigny Park, London SE5 8AF, UK.
114 Grove Road, Tring, Herts, HP23 5PA, UK.
Heliyon. 2016 Sep 22;2(9):e00160. doi: 10.1016/j.heliyon.2016.e00160. eCollection 2016 Sep.
Depression and bipolar illness are associated with a 2-3 fold increase in the prevalence of diabetes. However, it is unknown whether variation in mood affects glucose metabolism. The aim of this study was to assess whether changes in affect were related to fasting plasma glucose and glycated haemoglobin.
379 men and 441 women who took part in the 2003 Health Survey for England and had valid data for GHQ12 and fasting blood glucose were included. Mood variability was assessed by the General Health Questionnaire 12 (GHQ12). Fasting plasma glucose and glycated haemoglobin (HbA) were measured by standard laboratory methodology and their relationship to variability assessed using linear regression.
There was a significant inverse relationship between fasting blood glucose, but not HbA, and variability score (R = 0.327, p = 0.02) after adjusting for sociodemographic factors, anthropometric measurements, lifestyle, and use of medication.
This study has shown an inverse association between changes in affect and fasting plasma glucose. This unexpected finding suggests that the association between affect and glucose is more complex than previously thought. Fasting blood glucose may reflect the operation of homeostatic mechanisms that are disturbed in certain mental states and are associated, therefore, with altered risk of diabetes and related metabolic conditions. This may have implications for the management of those with such conditions and with mental disorders.
抑郁症和双相情感障碍与糖尿病患病率升高2至3倍有关。然而，情绪变化是否会影响葡萄糖代谢尚不清楚。本研究的目的是评估情绪变化是否与空腹血糖和糖化血红蛋白有关。
纳入了379名男性和441名女性，他们参与了2003年英格兰健康调查，且有关于一般健康问卷12项（GHQ12）和空腹血糖的有效数据。情绪变异性通过一般健康问卷12项（GHQ12）进行评估。空腹血糖和糖化血红蛋白（HbA）采用标准实验室方法测量，并使用线性回归评估它们与变异性的关系。
在调整社会人口学因素、人体测量指标、生活方式和药物使用情况后，空腹血糖与变异性得分之间存在显著的负相关关系，但糖化血红蛋白与变异性得分之间不存在这种关系（R = 0.327，p = 0.02）。
本研究表明情绪变化与空腹血糖之间存在负相关。这一意外发现表明，情绪与血糖之间的关联比之前认为的更为复杂。空腹血糖可能反映了某些精神状态下受到干扰的稳态机制的运作，因此与糖尿病及相关代谢疾病风险的改变有关。这可能对患有此类疾病和精神障碍的患者的管理具有启示意义。
