Geriatrics Division, Department of Medicine (DIMED), University of Padova, Via Giustiniani 2, 35128, Padua, Italy.
Respiratory Pathophysiology Division, University of Padova, Padua, Italy.
Lung. 2016 Dec;194(6):897-904. doi: 10.1007/s00408-016-9948-2. Epub 2016 Oct 3.
As studies examining the association between bone mineral density (BMD) and airflow limitation (AL) have produced conflicting results, the current one set out to analyze if and to what degree there are any correlations between these variables in a population of fit elderly women.
One hundred and twenty-one non-smoking, fit and healthy women (age ≥ 65 years) underwent anthropometric assessment, laboratory testing (serum 25-hydroxy vitamin D, parathormone, and cytokine levels), pulmonary function testing (PFT), and dual-energy X-ray absorptiometry to evaluate BMD values of the lumbar and femoral regions.
A significant positive association was found between FEV/FVC ratio (Tiffeneau index), a sensitive index of AL, and lumbar and femoral BMD; a 10 % increase in the FEV/FVC ratio resulted in a significant increase of 0.025 g/cm in the total hip (p = 0.05), 0.027 g/cm in the femoral neck (p = 0.02), 0.028 g/cm in the femoral trochanter (p = 0.01), and 0.047 g/cm in the lumbar (p = 0.03) BMDs. Binary logistic analyses demonstrated more than a threefold higher risk of low BMD values for the lowest FEV/FVC quartile in the lumbar (OR 4.62, 95 % CI 1.48-14.40, p = 0.008), total hip (OR 4.09, 95 % CI 1.28-13.05, p = 0.02 for the second quartile), and femoral trochanter regions (OR 3.90, 95 % CI 1.25-12.20, p = 0.02 for the third quartile).
AL was associated with a higher risk of reduced BMD in healthy, fit elderly women.
由于研究骨密度（BMD）和气流受限（AL）之间的关联产生了相互矛盾的结果，本研究旨在分析在健康的老年女性人群中，这些变量之间是否存在关联，以及关联程度如何。
121 名不吸烟、健康的老年女性（年龄≥65 岁）接受了人体测量评估、实验室检查（血清 25-羟维生素 D、甲状旁腺激素和细胞因子水平）、肺功能检查（PFT）和双能 X 射线吸收法，以评估腰椎和股骨区域的 BMD 值。
发现 AL 的敏感指标 FEV/FVC 比值（Tiffeneau 指数）与腰椎和股骨 BMD 呈显著正相关；FEV/FVC 比值增加 10%，总髋部（p=0.05）、股骨颈（p=0.02）、股骨粗隆（p=0.01）和腰椎（p=0.03）BMD 分别显著增加 0.025、0.027、0.028 和 0.047g/cm。二项逻辑分析显示，最低 FEV/FVC 四分位数的腰椎（OR 4.62，95%CI 1.48-14.40，p=0.008）、总髋部（OR 4.09，95%CI 1.28-13.05，p=0.02）和股骨粗隆区（OR 3.90，95%CI 1.25-12.20，p=0.02）的低 BMD 值的风险增加了三倍以上。
在健康、健康的老年女性中，AL 与较低的 BMD 风险相关。
